Leaders of small businesses need dynamic capabilities created through careful implementation of information technologies (ITs) to enhance efficiency, performance, and output. The purpose of this multicase study was to explore strategies leaders of small businesses used in developing countries to implement ITs for improved business performance. The framework for this study was the technology, organization, and environment model. The sample population consisted of 10 leaders of small businesses located in the Accra region of Ghana. The study participants had at least 5 years of experience working with small businesses that implemented IT. Data were collected from semistructured interviews and review of companies' strategic and project plans. The data analysis process included methodological triangulation, coding, the identification and congregation of themes, and the interpretation of inferences. Five themes emerged: top management support for IT implementation, investment in appropriate IT infrastructures, engaging in appropriate IT knowledge and skills training, creating an organizational culture of IT acceptance, and embracing legal and regulatory frameworks for IT. Findings from this study might assist leaders of small businesses in gaining insights into key IT strategies required for improving small business survivability. The implications of this study for positive social change include the potential to facilitate employment generation and reduce poverty in developing countries by improving small business performance.