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Modulation of vascular response by equolLau, Chin-tung. January 2008 (has links)
Thesis (M. Res.(Med.))--University of Hong Kong, 2008. / Includes bibliographical references (p. 83-98)
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Inhibitory effects of growth factors on proliferation of porcine smooth muscle cells in direct co-cultures /Mocherla, Supriya. January 2007 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for: Dept. of Chemical and Life Science Engineering. Bibliography: leaves 145-164. Also available online via the Internet.
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Calcium channel activity and force regulation in smooth muscle effects of polyamines and growth stimulation /Gomez, Maria. January 1998 (has links)
Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted. Includes bibliographical references.
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On the nature of the reversal of Mg2+-induced vascular relaxation by L-Name, a nitric oxide synthase inhibitor /Das, Rapti. January 1996 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 150-164).
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The role of ovarian hormones in the development and growth of uterine leiomyoma /Burroughs, Kevin Dale, January 1998 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 128-145). Available also in a digital version from Dissertation Abstracts.
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Organization of carbohydrate metabolism in vascular smooth muscle /Lloyd, Pamela G. January 2000 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2000. / "May 2000." Typescript. Vita. Includes bibliographical references (leaves 189-204). Also available on the Internet.
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Calcium channel activity and force regulation in smooth muscle effects of polyamines and growth stimulation /Gomez, Maria. January 1998 (has links)
Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted. Includes bibliographical references.
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Studies of oxidative metabolism in vascular smooth muscle glycogen utilization by the medial layer of bovine aorta ; respiration driven calcium transport in bovine aortic smooth muscle mitochondria /Rosenfeld, Michael Ellis. January 1981 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1981. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Diverse roles of PKC[alpha] in vascular smooth muscle contractionDykes, Ava Caudill. January 2006 (has links)
Theses (Ph. D.)--Marshall University, 2006. / Title from document title page. Includes abstract. Document formatted into pages: contains xiii, 122 p. including illustrations. Bibliography: Chap.I. p.28-33; Chap. II. p. 82-86; Chap. III p.115-116.
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Cell-wide web of cytoplasmic nanocourses coordinates calcium signallingDuan, Jingxian January 2018 (has links)
Ca2+ signals determine smooth muscle contraction and the switch from a contractile to a migratory-proliferative phenotype(s), which requires changes in gene expression. However, the mechanism by which different Ca2+ signals are selective for these processes is enigmatic. In the thesis, I built on the “panjunctional sarcoplasmic reticulum” hypothesis, and described the evidence in support of the view that a variety of Ca2+ pumps and release channels, with different kinetics and affinities for Ca2+, are strategically positioned within the cytoplasmic nanocourses of pulmonary arterial smooth muscle cells (PASMCs), and they serve to demarcate different Ca2+ signalling. Nanocourses of the SR are formed in the perinuclear, extraperinuclear, subplasmalemmal regions and the nucleus. Different subtypes of ryanodine receptors (RyRs) are targeted to those nanocourses. Immunocytochemistry results suggest that RyR1s was preferentially targeted to the subplasmalemmal and nuclear nanocourses of PASMCs, they gave rise to a spatially restricted Ca2+ signal within the nanocourses upon stimulation, without affecting global Ca2+ concentration. The Ca2+ signals in the subplasmalemmal nanocourses were shown to induce arterial smooth muscle cell relaxation. On the other hand, the RyR2 and 3 were shown to target to the perinuclear and extraperinuclear nanocourses. Upon stimulation, they generate propagating Ca2+ waves in the cytoplasmic nanocourses, which trigger arterial smooth muscle cell contraction. However, during this process, no Ca2+ transient was observed within the subplasmalemmal nanocourses, suggesting that the regulation of both contraction and relaxation of smooth muscle cells are achieved by spatially restricted Ca2+ signals within different nanocourses. Invaginations of the nucleoplasmic reticulum in arterial myocytes form trans-nuclear networks of cytoplasmic nanospaces, generate Ca2+ signals by strategically positioned Ca2+ pumps (SERCA1) and release channels (RyR1). Within a subpopulation of nuclear invaginations, evoked Ca2+ signals via ryanodine receptors exhibited spatial and temporal separation from adjacent Ca2+ signals within a single “activated” nuclear invagination, and also from those Ca2+ signals arising within different nuclear invaginations. Moreover, nuclear invaginations provide sites for transcriptional suppression, because lamin A and/or emerin line the entire surface of their inner nuclear membranes and co-localise with nesprin-1 positive puncta. More intriguing still, a subpopulation of these nuclear invaginations harboured punctate regions of colocalisation between lamin A and the suppressive heterochromatin mark H3K9me2, while emerin-positive invaginations harboured puncta of BAF (Barrior to autointegration factor) co-localisation and thus an alternative pathway to the regulation of gene expression. I propose that nuclear invaginations form cytoplasmic nanotubes within which nano-patterning of Ca2+ signals may support stochastic modulation of transcriptional suppressors. Together, the cytoplasmic nanocourses form a cell-wide web for Ca2+ signalling and the regulation of various arterial smooth muscle functions, ranging from the regulation of blood pressure by vasodilation and vasoconstriction to gene expression.
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