Psychobiographical research, with the use of psychological theory, allows us to uncover and unravel the life of an individual. This important area of research for the application of a psychological theory has, however, been under-utilized, especially in South Africa. The importance of psychobiographical case study research for the development and testing of theories of human development throughout the lifespan, has been supported by a number of academics in the field. The research subject was Sibella Margaretha (Isie) Krige. Isie (1870-1954) was married to General Jan Christiaan Smuts (1870-1950). He was a prominent South African and Commonwealth statesman, military leader, botanist and philosopher. Although much has been written on General Smuts, a psychobiography on the life of Isie had not been written yet. Isie was chosen as the research subject through purposive sampling. The study employed a qualitative psychobiographical research method, which aimed to explore and describe Isie’s psychological development in terms of Daniel Levinson’s (1996) theory of the Human Life Cycle. Collected data were analysed in accordance with Huberman and Miles’ (2000) approach. It integrated three sub-processes, namely data reduction, data display, as well as the drawing of conclusions and verification. The findings of the study indicate that Isie’s life was consistent with the pattern which Levinson (1996) identified. Isie was relatively successful in resolving the life tasks and transitional periods proposed by Levinson. The findings of the study also indicated that the development of Isie’s life structure was strongly influenced by a number of sociohistorical and global events. This research study has given a positive demonstration of the value of development theory. Furthermore, it emphasized the uniqueness of individuals in coping with the challenges of life. As a result it has opened up the possibility of perceiving people and their actions in a different way. Consequently, recommendations regarding the psychobiographical research design and methodology in future have been made.