Unintended pregnancy is a global public health threat that affects the lives of women, families, communities, and society. In 2008, the rate of unintended pregnancy in Ethiopia was 101 per 1,000 women aged 14 to 44 years. Although Ethiopia has experienced a steady increase in modern contraceptive use since 2004, this increase did not result in a proportional decline in unintended pregnancy, total fertility rates, or rapid population growth. In this cross-sectional study, associations between individual, interpersonal, community, and societal factors and contraceptive uptake were tested using a sample of 3,863 women aged 15 to 49 years who participated in the 2016 Ethiopian Demographic and Health Surveys. Statistically significant predictors of contraceptive use were included in the logistic regression model. Findings showed that age, education, marital status, type of residence, and wealth index reliably predicted contraceptive use. Increase in age, highest level of education, and wealth index were associated with 13%, 15%, and 65% increase in the odds of contraceptive use, respectively. Being married was associated with 85% decrease in the odds of contraceptive use and being from an urban residence was associated with 56% increase in the odds of contraceptive use. Results of the study can be used to develop targeted family planning interventions to increase contraceptive use and reduce unintended pregnancy, child and maternal mortality, total fertility rates, and rapid population growth in Ethiopia.