Under the umbrella of Internet of Things (IoT) and Internet of Everything (IoE), new applications with diverse requirements have emerged and the traditional System-on-Chips (SoCs) were unable to support them. Hence, new versatile SoC architectures were designed, like chiplets and Cloud-of-Chips (CoC). A key component of every SoC, is the on-chip interconnect technology, which is responsible for the communication between Processing Elements (PEs) of a system. Network-on-Chip (NoC) is the current widely used interconnect technology, which is a layered, scalable approach. However, the last years the high structural complexity together with the functional diversity and the challenges (QoS, high latency, security) of NoC motivated the researchers to explore alternatives of it. One NoC alternative that recently gained attention is the Software Defined Network-on-Chip (SDNoC). SDNoC originated from Software Defined Network (SDN) technology, which supports the dynamic nature of future networks and applications, while lowering operating costs through simplified hardware and software. Nevertheless, SDN technology designed for large scale networks. Thus, in order to be ported to micro-scale networks proper alterations and new hardware architectures need to be considered.In this thesis, an exploration of how to embed the SDN technology within the micro scale networks in order to provide secure and manageable communication, improve the network performance and reduce the hardware complexity is presented. Precisely, the design and implementation of an SDNoC architecture is thoroughly described followed by the creation and evaluation of a novel SDNoC communication protocol, called MicroLET, in order to provide secure and efficient communication within system components. Furthermore, the security aspect of SDNoC constitutes a big gap in the literature. Hence, it has been addressed by proposing a secure SDNoC Group Key Agreement (GKA) communication protocol, called SSPSoC, followed by the exploration of Byzantine faults within SDNoC and the investigation of a novel Hardware Trojan (HT) attack together with a proposed detection and defend method. / Doctorat en Sciences de l'ingénieur et technologie / info:eu-repo/semantics/nonPublished