The purpose of the present study was to compare the factor structure of distress, comprised of depression, anxiety, and somatization, across Turkey and the U.S., and to investigate the metric invariance of the instruments used to measure distress: The Beck Depression Inventory-II, The State Trait Anxiety Inventory Trait subscale, and TheSymptom Check List 90-R Somatization subscale. Data from 778 Turkish and U.S. participants were used for the analyses. It was found that depression, somatization, and anxiety are three distinct but related constructs for both Turkish and U.S. participants. It was also found that BDI-II, STAI-Trait, and SCL-90-R-Somatization do not have metric invariance across the two cultures, and these instruments do not measure the same distress construct across Turkey and U.S. Stated differently, distress as measured by these three instruments has different meanings for Turkish and U.S. participants. According to the results of a freelist analysis, somatic, cognitive, behavioral, and affective reactions to distress were equally salient for Turkish students. In contrast, affective and somatic reactions to distress had more salience for the U.S. participants.Some of the results obtained from the current study contradicted previous findings, while some were consistent. The results were consistent with the way depression, anxiety, and somatization are conceptualized in the DSM-IV (American Psychiatric Association, 1994) as separate constructs, but contradicted Krueger et al.'s findings (2003) and Broom's unitary model of personhood (2000, 2003). Results from the freelist analysis contradicted the previous findings indicating that Turkish individuals are more likely to somatize compared to individuals from the U.S. (Gureje et al., 1997). The methodological differences between the current study and the previous studies (Gureje et al., 1997), such as differences in the instrumentation and the educational levels of the participants, may have caused the observed differences in the findings. The results from the current study should be interpreted in light of its limitations, such as use of convenience sampling, instrumentation, and the effect of potential response biases. Future studies are needed to further investigate the cross-cultural metric invariance and item bias of BDI-II, STAI-Trait, and SCL-90-R-Somatization individually. / Department of Counseling Psychology and Guidance Services