The concentration of insulin-like growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines (A549, A427, SK-LU-1) expressed the type I IGF-I receptor protein and IGF-I stimulated the proliferation of low density plated (2000 cells/cm² growth area) carcinoma cells by 1.6- to 3- fold above control after a four day inCUbation period under serum-free conditions (A549, A427) or in the presence of 0.25% serum (SK-LU-1). In addition, when added to detergent-solubilized type I IGF receptors from A549 cells, IGF-I stimulated [1] a dose-dependent increase in the autophosphorylation of the type I IGF receptor, and [2] a dose-dependent increase (1.5- to 4-fold) in the phosphorylation of a tyrosine kinase-specific substrate. These results suggest that the growth promoting activity of IGF-I for the lung carcinoma cells was mediated through the activation of the type I IGF receptor. / Ph. D.

Tse Chui-ling. / "July 2004." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (p. 172-185). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web.

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Includes bibliography (leaves 191-219). Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound site if binding protein affinity is decreased. Discusses possible roles of these binding proteins in wound repair.

Includes bibliography (leaves 191-219). / Copy 2 lacks some pages. / x, 219 leaves : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound site if binding protein affinity is decreased. Discusses possible roles of these binding proteins in wound repair. / Thesis (M.D.)--Dept. of Surgery, University of Adelaide, 2001?

Addenda held in pocket pasted onto back end paper. / Bibliography: leaves 137-165. / xvi, 165 leaves : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / This thesis involves the retrospective investigation of the insulin-like growth factors and their binding proteins in the serum of children with chronic renal failure (CRF) and transplantation, before and after treatment with recombinant human growth hormone (rhGH). IGF-IGFBP complexes in pooled serum from prepubertal and pubertal children of both sexes with CRF and renal transplantation, before and after treatment with rhGH, are analysed by fast protein liquid chromatography under neutral conditions. / Thesis (M.D.)--University of Adelaide, Dept. of Paediatrics, 1997?

Graduation date: 1997

Thesis (Ph. D.)--Auburn University, 2008. / Abstract. Vita. Includes bibliographical references (p. 62-77).

Insulin-like growth factor-I (IGF-I) and its principle binding protein (IGFBP-3) are believed to play a role in mediating the anabolic effects of exercise. The purpose of this study was to assess the effect of 4 months of training on IGF-I and IGFBP-3, and to determine if changes in IGF-I or IGFBP-3 were related to changes in training status. Twelve varsity swimmers (5 males, 7 females) were tested pre-season, and again after 8 and 16 weeks of training. Measures included: VO2 max, nutritional status, athletic performance, subjective symptoms of overtraining, and serum levels of IGF-I and IGFBP-3. There was no significant change across time in VO2 max, athletic performance, IGF-I or IGFBP-3. Resting IGFBP-3 was positively correlated to symptoms of overtraining at week 0 (p=0.017), however, this relationship did not persist at week 8 or 16. These findings can not confirm that resting levels of IGF-I and IGFBP-3 are sensitive markers of training status. / ix, 105 leaves : ill. ; 29 cm.

Four experiments were conducted to determine the reproductive, metabolic, growth and IGF-I response to ultrasound selection for increased breast muscle thickness (MT) in Pekin ducks. Selection for body weight had a negative ( P < 0.05) effect on the reproductive performance while the selection for greater breast muscle thickness resulted in egg production, fertility and hatchability similar to those of the control line (C). Males from the MT line reached market weight at 6 wk but the breast muscle thickness improved from 6 to 7 wk. Compared to females from the C line, MT females had higher (P < 0.05) carcass yield, plasma glucose, and body protein; lower fat and plasma uric acid; and no difference (P > 0.05) in plasma triglycerides and total cholesterol. Males responded more efficiently to increasing dietary protein than females, and males selected for greater MT can be slaughtered at an earlier age when a high protein feeding program (HP) was followed. Males receiving HP had greater (P < 0.05) pectoralis muscles yield, longer keel bone, and lower breast skin and total skin fat yields. Female dissection data show similar (P > 0.05) effects of high and medium protein programs. Increasing dietary protein reduced (P < 0.05) carcass fat and increased (P < 0.05) crude protein (CP). In vivo breast muscle measurement correlated positively (P < 0.05) with body weight, pectoralis yield, and keel bone length. Birds with higher pectoralis yield tended to have more CP and less fat in their carcasses. A low correlation (r = 0.19) was found for the caliper measurement of breast skin plus fat thickness and carcass fat. We determined the metabolic differences between lean and fat male and female ducks, associated metabolic parameters and body composition, and assessed the difference between two feeding solutions for the determination of metabolic endogenous losses. There was a positive correlation between breast muscle:total breast muscle thickness ratio (MT/TO