Depression is a serious mental health condition which affects millions of people around the world. The biomedical model of illness categorises depression as a clinical disorder and primarily physiological in origin. However, conceptions of mental health such as depression may vary contextually because they are shaped by cultural understandings of illness. Research is encouraged to further investigate the context and culture of those affected, in an effort to better respond to local realities and psychologies. A qualitative research approach was utilised in this study, with social constructionism as its paradigmatic point of departure. One in-depth semi-structured interview was conducted with five South African Indian Muslim women from the greater Johannesburg area. Thematic analysis was used to interpret the interviews. Four main themes surfaced; what depression is and is not, causes of depression, treatment and stigma. Each main theme included various sub-themes. In addition, culture and gender arose from the analysis, as influential constructs across these themes. These themes highlighted the complexity and importance of culture and gender on the constructions of depression, for these women. These findings encourage the inclusion for cultural sensitivity in treating Indian Muslim women, and responding to the broader community’s needs. This can assist mental healthcare professionals to integrate culture and gender, as constructs, in offering more effective and appropriate treatment for lay understandings of depression, to respond to local realities. Furthermore, these findings add to a growing body of research which attempts to broaden and deepen understandings of mental health and culture, to better respond to patient’s needs. / Mini dissertation (MA (Clinical Psychology))--University of Pretoria, 2021. / Psychology / MA (Clinical Psychology) / Unrestricted