<p>Imaging and computer vision systems deployed in real-world environments face the challenge of accommodating a wide range of lighting conditions. However, the cost, the demand for high resolution, and the miniaturization of imaging devices impose physical constraints on sensor design, limiting both the dynamic range and effective aperture size of each pixel. Consequently, conventional CMOS sensors fail to deliver satisfactory capture in high dynamic range scenes or under photon-limited conditions, thereby impacting the performance of downstream vision tasks. In this thesis, we address two key problems: 1) exploring the utilization of spatial multiplexing, specifically spatially varying exposure tiling, to extend sensor dynamic range and optimize scene capture, and 2) developing techniques to enhance the robustness of object detection systems under photon-limited conditions.</p> <p><br></p> <p>In addition to challenges imposed by natural environments, real-world vision systems are susceptible to adversarial attacks in the form of artificially added digital content. Therefore, this thesis presents a comprehensive pipeline for constructing a robust and scalable system to counter such attacks.</p>