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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Development and application of new cancer-specific contrast agents for tumour detection by magnetic resonance imagingShahbazi-Gahrouei, Dariyoush, University of Western Sydney, Nepean, School of Science January 2000 (has links)
Four new potential MR imaging contrast agents were synthesised. Gadolinium-hematoporphyrin (Gd-H) was produced by inserting gadolinium into the naturally occurring porphyrin,hematoporphyrin.Gadolinium-tetra-carboranylmethoxyphenyl-porphyrin acetate (Gd-TCP)was similarly synthesised by gadolinium insertion into the synthetic porphyrin, 1, 6, 11, 16-tetra-[3-(carboranylmethoxy)phenyl] porphyrin. The monoclonal antibodies, 9.2.27 against melanoma and WM53 against leukaemia cell lines, were conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (Gd-cDTPAa), yielding the attachment of chelate DTPA to the antibodies. Gadolinium ion was inserted into the chelate DTPA, thus labelled both these antibodies with Gd-DTPA. Overall, with the satisfactory low levels of gadolinium in the liver, kidneys, and spleen, and good tumour uptake, gadolinium antibody conjugates has considerable potential for further diagnostic applications of MR imaging. / Doctor of Philosophy (PhD)
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走査透過電子顕微鏡における弾性・非弾性散乱信号のオンライン・ディジタル演算処理日比野, 倫夫, 下山, 宏, 杉山, せつ子, 花井, 孝明 03 1900 (has links)
科学研究費補助金 研究種目:試験研究 課題番号:63850078 研究代表者:日比野 倫夫 研究期間:1988-1989年度
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