The objective of this study is to apply digital image processing (DIP) techniques to optical coherence tomography (OCT) images and develop computer-based non-subjective quantitative analysis, which can be used as diagnostic aids in early detection of dental caries. This study first compares speckle reduction effects on raw OCT image data by implementing spatial-domain and transform-domain speckle filtering. Then region-based contour search and global thresholding techniques examine digital OCT images with possible lesions to identify and highlight the presence of features indicating early stage dental caries. The outputs of these processes, which explore the combination of image restoration and segmentation, can be used to distinguish lesion from normal tissue and determine the characteristics prior to, during, and following treatments. The combination of image processing and analysis techniques in this thesis shows potential of detecting early stage caries lesion successfully.

The objective of this study is to apply digital image processing (DIP) techniques to optical coherence tomography (OCT) images and develop computer-based non-subjective quantitative analysis, which can be used as diagnostic aids in early detection of dental caries. This study first compares speckle reduction effects on raw OCT image data by implementing spatial-domain and transform-domain speckle filtering. Then region-based contour search and global thresholding techniques examine digital OCT images with possible lesions to identify and highlight the presence of features indicating early stage dental caries. The outputs of these processes, which explore the combination of image restoration and segmentation, can be used to distinguish lesion from normal tissue and determine the characteristics prior to, during, and following treatments. The combination of image processing and analysis techniques in this thesis shows potential of detecting early stage caries lesion successfully.

Approved for public release; distribution is unlimited / This thesis supplements and updates previous research completed in the digital analysis of rocket motor combustion chamber holographic images. In particular this thesis deals with the software code optimization of existing automatic data retrieval algorithms that are used to extract useful particle information from the holograms using a microcomputer-based imaging system. Two forms of optimization were accomplished, the application of an optimizing FORTRAN compiler to the existing FORTRAN programs and the complete rewrite of the programs in the C language using an optimizing compiler. The overall results achieved were a reduction in executable program size and a significant decrease in program execution speed. / http://archive.org/details/codeoptimization00kaes / Lieutenant Commander, United States Navy

Phase-extraction from fringe patterns is an inevitable procedure in the field of optical metrology and interferometry. However, speckle noise will introduce and influence the precision of wrapped phase map when a coherent light is used. In this thesis, we use the bidimensional empirical mode decomposition (BEMD) to perform the speckle-reduction. Moreover, different interpolation method in BEMD will be used to compare their performance in speckle-reduction. Finally, the database will be developed to make the BEMD a robotic tool to reduce noises. And the database also points out that the performance of BEMD is highly related to the fringe period, the fringe visibility, and the SNR of speckle noise.

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[Truncated abstract] Transrectal ultrasound (TRUS) has become the urologist’s primary tool for diagnosing and staging prostate cancer due to its real-time and non-invasive nature, low cost, and minimal discomfort. However, the interpretation of a prostate ultrasound image depends critically on the experience and expertise of a urologist and is still difficult and subjective. To overcome the subjective interpretation and facilitate objective diagnosis, computer aided analysis of ultrasound images of the prostate would be very helpful. Computer aided analysis of images may improve diagnostic accuracy by providing a more reproducible interpretation of the images. This thesis is an attempt to address several key elements of computer aided analysis of ultrasound images of the prostate. Specifically, it addresses the following tasks: 1. modelling B-mode ultrasound image formation and statistical properties; 2. reducing ultrasound speckle; and 3. extracting prostate contour. Speckle refers to the granular appearance that compromises the image quality and resolution in optics, synthetic aperture radar (SAR), and ultrasound. Due to the existence of speckle the appearance of a B-mode ultrasound image does not necessarily relate to the internal structure of the object being scanned. A computer simulation of B-mode ultrasound imaging is presented, which not only provides an insight into the nature of speckle, but also a viable test-bed for any ultrasound speckle reduction methods. Motivated by analysis of the statistical properties of the simulated images, the generalised Fisher-Tippett distribution is empirically proposed to analyse statistical properties of ultrasound images of the prostate. A speckle reduction scheme is then presented, which is based on Mallat and Zhong’s dyadic wavelet transform (MZDWT) and modelling statistical properties of the wavelet coefficients and exploiting their inter-scale correlation. Specifically, the squared modulus of the component wavelet coefficients are modelled as a two-state Gamma mixture. Interscale correlation is exploited by taking the harmonic mean of the posterior probability functions, which are derived from the Gamma mixture. This noise reduction scheme is applied to both simulated and real ultrasound images, and its performance is quite satisfactory in that the important features of the original noise corrupted image are preserved while most of the speckle noise is removed successfully. It is also evaluated both qualitatively and quantitatively by comparing it with median, Wiener, and Lee filters, and the results revealed that it surpasses all these filters. A novel contour extraction scheme (CES), which fuses MZDWT and snakes, is proposed on the basis of multiresolution analysis (MRA). Extraction of the prostate contour is placed in a multi-scale framework provided by MZDWT. Specifically, the external potential functions of the snake are designated as the modulus of the wavelet coefficients at different scales, and thus are “switchable”. Such a multi-scale snake, which deforms and migrates from coarse to fine scales, eventually extracts the contour of the prostate