Objective. Brain computer interface (BCI) technology can be important for those unable to communicate due to loss of muscle control. Given that the P300 Speller provides a relatively slow rate of communication, highly accurate classification is of great importance. Previous studies have shown that alternative stimuli (e.g. faces) can improve BCI speed and accuracy. The present study uses two new alternative stimuli, locations and graspable tools. Functional MRI studies have shown that images of familiar locations produce brain responses in the parahippocampal place area and graspable tools produce brain responses in premotor cortex. Approach. The current studies show that location and tool stimuli produce unique and discriminable brain responses that can be used to improve offline classification accuracy. Experiment 1 presented face stimuli and location stimuli and Experiment 2 presented location and tool stimuli. Main results. In both experiments, offline results showed that a stimulus specific classifier provided higher accuracy, speed, and bit rate. Significance. This study was used to provide preliminary offline support for using unique stimuli to improve speed and accuracy of the P300 Speller. Additional experiments should be conducted to examine the online efficacy of this novel paradigm.

Objective. Dry electrodes have an advantage over gel-based 'wet' electrodes by providing quicker set-up time for electroencephalography recording; however, the potentially poorer contact can result in noisier recordings. We examine the impact that this may have on brain-computer interface communication and potential approaches for mitigation. Approach. We present a performance comparison of wet and dry electrodes for use with the P300 speller system in both healthy participants and participants with communication disabilities (ALS and PLS), and investigate the potential for a data-driven dynamic data collection algorithm to compensate for the lower signal-to-noise ratio (SNR) in dry systems. Main results. Performance results from sixteen healthy participants obtained in the standard static data collection environment demonstrate a substantial loss in accuracy with the dry system. Using a dynamic stopping algorithm, performance may have been improved by collecting more data in the dry system for ten healthy participants and eight participants with communication disabilities; however, the algorithm did not fully compensate for the lower SNR of the dry system. An analysis of the wet and dry system recordings revealed that delta and theta frequency band power (0.1-4 Hz and 4-8 Hz, respectively) are consistently higher in dry system recordings across participants, indicating that transient and drift artifacts may be an issue for dry systems. Significance. Using dry electrodes is desirable for reduced set-up time; however, this study demonstrates that online performance is significantly poorer than for wet electrodes for users with and without disabilities. We test a new application of dynamic stopping algorithms to compensate for poorer SNR. Dynamic stopping improved dry system performance; however, further signal processing efforts are likely necessary for full mitigation.

P300 spellers can provide a means of communication for individuals with severe neuromuscular limitations. However, its use as an effective communication tool is reliant on high P300 classification accuracies (>70‰) to account for error revisions. Error-related potentials (ErrP), which are changes in EEG potentials when a person is aware of or perceives erroneous behavior or feedback, have been proposed as inputs to drive corrective mechanisms that veto erroneous actions by BCI systems. The goal of this study is to demonstrate that training an additional ErrP classifier for a P300 speller is not necessary, as we hypothesize that error information is encoded in the P300 classifier responses used for character selection. We perform offline simulations of P300 spelling to compare ErrP and non-ErrP based corrective algorithms. A simple dictionary correction based on string matching and word frequency significantly improved accuracy (35-185%), in contrast to an ErrP-based method that flagged, deleted and replaced erroneous characters (-47-0‰). Providing additional information about the likelihood of characters to a dictionary-based correction further improves accuracy. Our Bayesian dictionary-based correction algorithm that utilizes P300 classifier confidences performed comparably (44-416%) to an oracle ErrP dictionary-based method that assumed perfect ErrP classification (43-433%).

This study examines the effects of expanding the classical P300 feature space on the classification performance of data collected from a P300 speller paradigm [Farwell LA, Donchin E. Talking off the top of your head: toward a mental prosthesis utilizing event-related brain potentials. Electroenceph Clin Neurophysiol 1988;70:510-23]. Using stepwise linear discriminant analysis (SWLDA) to construct a classifier, the effects of spatial channel selection, channel referencing, data decimation, and maximum number of model features are compared with the intent of establishing a baseline not only for the SWLDA classifier, but for related P300 speller classification methods in general. By supplementing the classical P300 recording locations with posterior locations, online classification performance of P300 speller responses can be significantly improved using SWLDA and the favorable parameters derived from the offline comparative analysis.

No description available.

<p>Brain-computer interfaces (BCI) have the potential to restore communication or control abilities in individuals with severe neuromuscular limitations, such as those with amyotrophic lateral sclerosis (ALS). The role of a BCI is to extract and decode relevant information that conveys a user's intent directly from brain electro-physiological signals and translate this information into executable commands to control external devices. However, the BCI decision-making process is error-prone due to noisy electro-physiological data, representing the classic problem of efficiently transmitting and receiving information via a noisy communication channel. </p><p>This research focuses on P300-based BCIs which rely predominantly on event-related potentials (ERP) that are elicited as a function of a user's uncertainty regarding stimulus events, in either an acoustic or a visual oddball recognition task. The P300-based BCI system enables users to communicate messages from a set of choices by selecting a target character or icon that conveys a desired intent or action. P300-based BCIs have been widely researched as a communication alternative, especially in individuals with ALS who represent a target BCI user population. For the P300-based BCI, repeated data measurements are required to enhance the low signal-to-noise ratio of the elicited ERPs embedded in electroencephalography (EEG) data, in order to improve the accuracy of the target character estimation process. As a result, BCIs have relatively slower speeds when compared to other commercial assistive communication devices, and this limits BCI adoption by their target user population. The goal of this research is to develop algorithms that take into account the physical limitations of the target BCI population to improve the efficiency of ERP-based spellers for real-world communication. </p><p>In this work, it is hypothesised that building adaptive capabilities into the BCI framework can potentially give the BCI system the flexibility to improve performance by adjusting system parameters in response to changing user inputs. The research in this work addresses three potential areas for improvement within the P300 speller framework: information optimisation, target character estimation and error correction. The visual interface and its operation control the method by which the ERPs are elicited through the presentation of stimulus events. The parameters of the stimulus presentation paradigm can be modified to modulate and enhance the elicited ERPs. A new stimulus presentation paradigm is developed in order to maximise the information content that is presented to the user by tuning stimulus paradigm parameters to positively affect performance. Internally, the BCI system determines the amount of data to collect and the method by which these data are processed to estimate the user's target character. Algorithms that exploit language information are developed to enhance the target character estimation process and to correct erroneous BCI selections. In addition, a new model-based method to predict BCI performance is developed, an approach which is independent of stimulus presentation paradigm and accounts for dynamic data collection. The studies presented in this work provide evidence that the proposed methods for incorporating adaptive strategies in the three areas have the potential to significantly improve BCI communication rates, and the proposed method for predicting BCI performance provides a reliable means to pre-assess BCI performance without extensive online testing.</p> / Dissertation

A Brain Computer Interface (BCI) provides a means, to control external devices, through the electrical activity of the brain, bypassing motor movement. Recent years have seen an increase in the application of P300 cognitive potential as a control and/or communication signal for the motor restoration in paralyzed patients, such as those in the later stages of ALS (Amyotrophic lateral sclerosis). Although many of these patients are in locked-in state i.e. where motor control is not possible, their cognition is known to remain intact. The P300 speller paradigm explored in this study relying on this cognition represented by the P300 peak potential in EEG (Electroencephalography) signals to restore communication. The conventional visual oddball paradigms used to elicit P300 potential may not be the optimum choice due to their need for precise eye-gazing, which may be challenge for many patients. This study introduces a novel paradigm with motor imagery as a secondary after-stimulus task in a traditional visual oddball paradigm for P300 Speller application. We observed increased P300 peak amplitude as well as the event-related desynchronization (ERD) associated with motor imagery in six healthy novice subjects. Acceptable detection accuracy was obtained in the five-trial averaged signals from 250 ms to 750 ms after the visual stimulation, whereby the early visual evoked potentials were excluded from classification. As an enhancement, efforts are being made to assess implementation by motor imagery embedded in an auditory oddball paradigm which would minimize the need for eye-gazing further. We can conclude from the results of this study that the proposed paradigm with motor imagery embedded in a traditional visual oddball paradigm might be a feasible option for communication restoration in paralyzed patients.

In this study, a P300 based Brain-Computer Interface (BCI) system design is realized by the implementation of the Spelling Paradigm. The main challenge in these systems is to improve the speed of the prediction mechanisms by the application of different signal processing and pattern classification techniques in BCI problems. The thesis study includes the design and implementation of a 10 channel Electroencephalographic (EEG) data acquisition system to be practically used in BCI applications. The electrical measurements are realized with active electrodes for continuous EEG recording. The data is transferred via USB so that the device can be operated by any computer. v Wiener filtering is applied to P300 Speller as a signal enhancement tool for the first time in the literature. With this method, the optimum temporal frequency bands for user specific P300 responses are determined. The classification of the responses is performed by using Support Vector Machines (SVM&rsquo / s) and Bayesian decision. These methods are independently applied to the row-column intensification groups of P300 speller to observe the differences in human perception to these two visual stimulation types. It is observed from the investigated datasets that the prediction accuracies in these two groups are different for each subject even for optimum classification parameters. Furthermore, in these datasets, the classification accuracy was improved when the signals are preprocessed with Wiener filtering. With this method, the test characters are predicted with 100% accuracy in 4 trial repetitions in P300 Speller dataset of BCI Competition II. Besides, only 8 trials are needed to predict the target character with the designed BCI system.

Η παρούσα διπλωματική έχει ως σκοπό να συνδέσει την λειτουργία υπάρχοντος ορθογράφου με συγκεκριμένη δομή αποθήκευσης και αναζήτησης λέξεων. Κριτήρια του ορθογράφου είναι να είναι ανοιχτού κώδικα και σκοπός είναι να του προστεθεί η δυνατότητα να λειτουργεί με ακυκλικούς γράφους, ντετερμινιστικούς ή μη. Τα πλεονεκτήματα της νέας δομής και λειτουργίας του ορθογράφου είναι πολλαπλά και παρουσιάζονται στη πορεία της διπλωματικής. Αν και οι δοκιμές που έγιναν, δεν αναδεικνύουν τα πλεονεκτήματα αυτά, σε θεωρητικό επίπεδο η εξέλιξη μπορεί να είναι μεγάλη, και σε ταχύτητα αλλά και σε απόδοση. / Target of this project is to connect the proccess of an existing speller to a spesific structure of storing and searching words. Basic criteria of this speller are: open source, capability to work with acyclic graphs, deteministic or not. The advantages of this new structure and proccess of the speller are presented in this project.

Les interfaces cerveau-machine (ICM) permettent de contrôler une machine directement à partir de l'activité cérébrale. Le P300-Speller, en particulier, pourrait offrir à des patients complètement paralysés, la possibilité de communiquer sans l'aide de la parole ou du geste. Nous avons cherché à améliorer cette communication en étudiant la coadaptation entre cerveau et machine. Nous avons d'abord montré que l'adaptation d'un utilisateur peut être partiellement perçue, en temps-réel, à travers les modulations de sa réponse électrophysiologique aux feedbacks de la machine. Nous avons ensuite proposé, testé et évalué les effets sur l'utilisateur de plusieurs approches permettant d'améliorer l'interaction, notamment : - la correction automatique des erreurs, grâce à la reconnaissance en temps-réel des réponses aux feedbacks ; - une stimulation dynamique permettant de diminuer le risque d'erreur tout en réduisant l'inconfort lié aux stimulations ; - un processus automatique de décision adaptative, en fonction de l'état de vigilance du sujet. Nos résultats montrent la présence de réponses aux feedbacks spécifiques des erreurs et modulées par l'attention ainsi que par la surprise du sujet face au résultat de l'interaction. Par ailleurs, si l'efficacité de la correction automatique est variable d'un sujet à l'autre, le nouveau mode de stimulation comme la décision adaptative apparaissent comme très avantageux et leur utilisation a un effet positif sur la motivation. Dans la perspective d'études cliniques pour évaluer l'utilité des ICM pour la communication, ces travaux soulignent et quantifient l'intérêt de développer des interfaces capables de s'adapter à chaque utilisateur.