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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Spermatogenesis of normal and of hybrid pigeons a dissertation, submitted to the faculty of the Graduate School of Arts, Literature, and Science, in candidacy for the degree of doctor of philosophy; Department of Zoology /

Guyer, Michael F. January 1900 (has links)
Thesis (Ph. D.)--University of Chicago, 1900. / Includes bibliographical references (p. 57-59).
2

Spermatogenesis of normal and of hybrid pigeons a dissertation, submitted to the faculty of the Graduate School of Arts, Literature, and Science, in candidacy for the degree of doctor of philosophy; Department of Zoology /

Guyer, Michael F. January 1900 (has links)
Thesis (Ph. D.)--University of Chicago, 1900. / Includes bibliographical references (p. 57-59).
3

Spermatogenesis of normal and of hybrid pigeons : a dissertation, submitted to the faculty of the Graduate School of Arts, Literature, and Science, in candidacy for the degree of doctor of philosophy; Department of Zoology /

Guyer, Michael F. January 1900 (has links)
Thesis (Ph. D.)--University of Chicago, 1900. / Bibliography: p. 57-59. Also available on the Internet. Also issued online.
4

Some biochemical aspects of the motility of spermatozoa.

January 1979 (has links)
by Will W.M. Lee. / Thesis (M.Phil.) - Chinese University of Hong Kong. / Bibliography: leaves 101-110. / Chapter CHAPTER I --- GENERAL INTRODUCTION / Chapter A --- Spermatogenesis --- p.1 / Chapter B --- Sperm Maturation --- p.2 / Chapter C --- Ejaculation --- p.3 / Chapter D --- Sperms in Fertilization --- p.3 / Chapter E --- Aim of Spermatozoal Motility Studies --- p.7 / Chapter CHAPTER II --- AN ASSAY TO MEASURE THE SPERMATOZOAL PROGRESSIVE MOTION / INTRODUCTION --- p.8 / MATERIALS AND METHODS --- p.15 / Chapter A --- Sample Collection --- p.15 / Chapter B --- Cell Wash --- p.17 / Chapter C --- Media --- p.18 / Chapter D --- Motility Assay Chamber --- p.18 / RESULTS AND DISCUSSIONS --- p.22 / Chapter A --- Sperm Entry --- p.22 / Chapter B --- Sperm Motility --- p.32 / Chapter CHAPTER III --- EFFECT OF VARIOUS GROUPS OF CHEMICALS ON THE MOTILITY OF SPERMATOZOA / INTRODUCTION --- p.48 / MATERIALS AND METHODS --- p.55 / RESULTS AND DISCUSSIONS --- p.57 / Chapter A --- Energy Source --- p.57 / Chapter B --- "Phosphodiesterase Inhibitors and Cyclic 3',5'-Adenosine Monophosphate (cAMP)" --- p.59 / Chapter C --- p-Nitrophenyl Compounds --- p.64 / Chapter D --- Motility of Spermatozoa from Addicted Rat and Effect of Morphine on tozoa In VitroSperma- --- p.68 / Chapter E --- Metallic Ions and EDTA --- p.68 / Chapter CHAPTER IV --- EFFECT OF SEMINAL PLASMA ON SPERM MOTILITY --- p.77 / INTRODUCTION / MATERIALS AND METHODS --- p.79 / RESULTS --- p.82 / DISCUSSIONS --- p.98 / REFERENCES --- p.101 / Chapter APPENDIX I --- Spermatozoa Repellent as a Contraceptive --- p.111 / Chapter APPENDIX II --- Effect of p -Nitrophenylglycerol on Motility of Rat Epididymal Spermatozoa --- p.117
5

Development of culture methods for spermatogonial stem cells and ectopic testicular xenografting in the bull

Oatley, Jon Michael, January 2004 (has links) (PDF)
Thesis (Ph. D.)--Washington State University. / Includes bibliographical references.
6

Spermatogenesis in the Belostomatidae II. The chromosomes and cytoplasmic inclusions in the male germ cells of Belostoma flumineum Say, Lethocerus americanus Leidy, and Benacus griseus Say ...

Chickering, Arthur Merton, January 1900 (has links)
Thesis (Ph. D.)--University of Michigan, 1927. / Descriptive letterpress on versos facing the plates. "Reprinted from the Journal of morphology and physiology, vol. 44, no. 3, December, 1927." Bibliography: p. 590-592.
7

Molecular and functional characterization of a testis-specific TRS4 gene in spermatogenesis

Tang, Yue-bun, Alan. January 2010 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2010. / Includes bibliographical references (p. 161-190). Also available in print.
8

A study on the role of temperature repressed sequence 4 (Trs4) in spermatogenesis

So, Kam-hei., 蘇錦熙. January 2011 (has links)
Heat stress inhibits spermatogenesis partly by inducing apoptosis in the testicular germ cells. Using a cryptochid rat model, we identified a temperature-related ESTs 4 (TRS4) transcript from rat testis. Trs4 mRNA is specifically expressed in the mouse and rat testis from postnatal day 21 and 28 days onwards, respectively. Trs4 protein is located mainly in the elongating spermatids and mature spermatozoa at the acrosome and tail regions. Using a yeat-2-hybrid screening, Trs4 was found to bind Gstmu1, Rslh-2 and Ddc8 proteins. To further characterize the functional role of Trs4 in spermatogenesis, and study how Trs4 interacts its binding proteins for cellular functions, we aimed (1) to screen putative ES cells with Trs4 floxed allele for knockout mice generation, (2) to generate Trs4 deletion constructs and study the cellular localization of Trs4 and its putative binding partners in transfected spermatocyte GC-2spd(s) cell line, (3) to study how heat-treatment regulates the expression of Trs4 and apoptotic molecules. The Trs4 conditional targeting vector was constructed by flanking exons 4-6 with two LoxP sites and electroporated into ES cells. After screening of 480 clones, positive ES cell clones were identified by Southern blotting using 5’- and 3’- probes. Three putative positive clones were identified carrying the floxed allele. Trs4 protein contains putative ubiquitin-like motif (a.a. 119-224), IQ-calmodulin binding motif (a.a. 334-362) and a overlapping bipartite nuclear localization signal (BNL) (a.a. 346-362). Transfection of EGFP fused Trs4 truncated protein demonstrated that the IQ-calmodulin binding motif and BNL signal was important for localization of Trs4 protein in the cytoplasmic/Golgi regions; while the N-terminal contains ubiquitin-like motif and the C-terminal regions direct the expression of the EGFP-fusion protein mainly to the nucleus. The full-length sequence of Trs4 binding partners: Gstmu1, Rshl-2 and Ddc8 were cloned into the pDsRedmonomer-C1 vector, giving red fluorescence protein in the transfected cells. They were colocalized with EGFP-Trs4 in the cytoplasm of the cells, confirming that Trs4 and its interacting protein is likely interact with each other in vivo. As Trs4 colocalize with Gstmu1, a modulator of mitochondrial-dependent pathway in apoptosis, it is suggested that Trs4 is an upstream regulator of apoptosis under heat treatment in germ cells. The functional roles of Trs4 protein Trs4 and apoptotic molecules. The Trs4 conditional targeting vector was constructed by flanking exons 4-6 with two LoxP sites and electroporated into ES cells. After screening of 480 clones, positive ES cell clones were identified by Southern blotting using 5’- and 3’- probes. Three putative positive clones were identified carrying the floxed allele. Trs4 protein contains putative ubiquitin-like motif (a.a. 119-224), IQ-calmodulin binding motif (a.a. 334-362) and a overlapping bipartite nuclear localization signal (BNL) (a.a. 346-362). Transfection of EGFP fused Trs4 truncated protein demonstrated that the IQ-calmodulin binding motif and BNL signal was important for localization of Trs4 protein in the cytoplasmic/Golgi regions; while the N-terminal contains ubiquitin-like motif and the C-terminal regions direct the expression of the EGFP-fusion protein mainly to the nucleus. The full-length sequence of Trs4 binding partners: Gstmu1, Rshl-2 and Ddc8 were cloned into the pDsRedmonomer-C1 vector, giving red fluorescence protein in the transfected cells. They were colocalized with EGFP-Trs4 in the cytoplasm of the cells, confirming that Trs4 and its interacting protein is likely interact with each other in vivo. As Trs4 colocalize with Gstmu1, a modulator of mitochondrial-dependent pathway in apoptosis, it is suggested that Trs4 is an upstream regulator of apoptosis under heat treatment in germ cells. The functional roles of Trs4 protein / published_or_final_version / Obstetrics and Gynaecology / Master / Master of Philosophy
9

Blood testis barrier: its biology and significance in spermatogenesis

Mok, Ka-wai., 莫嘉維. January 2012 (has links)
Spermatogenesis takes place in the seminiferous epithelium and it is a tightly regulated process that produces spermatozoa from spermatogonia. During spermatogenesis, germ cells have to traverse the seminiferous epithelium, from basal to adluminal compartment and finally reach the luminal edge of the seminiferous tubules at spermiation. During the transit of germ cells, they have to get across the blood-testis barrier (BTB), which is formed by adjacent Sertoli cells. Thus, although BTB is considered as one of the tightest blood-tissue barrier, the BTB undergoes cyclic restructuring to “open” transiently for the translocation of germ cells. However, the integrity of the BTB has to remain intact as the BTB is essential for the developing germ cells behind the barrier. For example, the BTB serves as an immunological barrier to “seal” developing germ cells from the systemic circulation. Since how the BTB restructuring is regulated remains elusive, the study herein aims to provide some information regarding to this events. The importance of the BTB to spermatogenesis was demonstrated by treating rats with 50 (lowdose) or 250 mg/kg b.w (high-dose) of adjudin. Although the BTB of rats was perturbed in both groups at week 6 post treatment, as shown by an in vivo BTB functional assay, the BTB of the low-dose group was found to have “resealed” at week 20 whereas the BTB of the high-dose group remained disrupted. Besides, despite almost all germ cells were depleted in both group of rats upon week 2 post treatment, spermatogonia were still present in the testis of rats no matter high- or low-dose of adjudin was used. However, spermatogenesis only recovered in low-dose treated group, which have an intact BTB. This suggests that after spermatogenesis is disrupted, its regeneration of spermatogenesis needs more than the existence of spermatogonia in which an intact BTB is required. After demonstrating the necessity of the BTB for spermatogenesis, the next question I addressed was how its restructuring was modulated. The involvement of mammalian target of rapamycin (mTOR) in manipulating the BTB was investigated. mTOR is able to form two distinct signaling complexes namely mTOR complex 1 (mTORC1) or mTORC2 by assembling with raptor or rictor, respectively. rpS6, which is a downstream molecule of mTORC1 was activated specifically during BTB restructuring and knockdown of rpS6 in cultured Sertoli cells was able to promote the TJ-barrier by inducing deposition of F-actin and BTB proteins at the cell-cell interface, suggesting the role of phosphorylated rpS6 is to “open” the BTB for the transit of spermatocytes. Moreover, the knockdown of rictor led to perturbation of TJ-barrier formed by cultured Sertoli cells via a PKC-α depending actin reorganization, causing internalization of BTB proteins. This indicates mTORC2 is necessary for the maintenance of the BTB and hence the two mTOR complexes work antagonistically to regulate the BTB in which mTORC1 is activated to promote the BTB restructuring while the expression of mTORC2 is essential to sustain the BTB integrity. / published_or_final_version / Biological Sciences / Doctoral / Doctor of Philosophy
10

Identification of interacting partners of LFA-1 in the testis

Lam, Hang-yee, Chloe, 林倖而 January 2013 (has links)
published_or_final_version / Biological Sciences / Master / Master of Philosophy

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