The COVID-19 pandemic is a global traumatic stressor affecting millions of individuals worldwide. Traumatic events often cause significant resource loss and negatively affect mental health and emotional well-being. In the wake of trauma, many people draw on religious or spiritual faith to cope with adversity and suffering. One construct that has received increased attention within the field of religious/spiritual coping is spiritual fortitude (SF). SF refers to the one's ability to consistently draw on spiritual resources to transcend negative emotions in the face of stressors. In this study, I recruited 255 participants who had lived during the COVID-19 pandemic. Participants completed measures of resource loss, religious/spiritual struggles, SF, religious commitment, depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms. The overall results suggested participants utilized a wide range of coping strategies (e.g., religious/spiritual, social, health practice) during the COVID-19 pandemic. Both resource loss and religious/spiritual struggles were positively associated with mental distress. SF buffered the deleterious relationship between resource loss and mental distress. Specifically, for individuals high in SF, the relationship between resource loss and mental distress was weaker than for individuals low in SF.