Current research indicates that the inability to spontaneously communicate needs or wants may result in the acquisition of unconventional forms of requesting such as aggression and tantrums. This in turn limits the amount of access that students with autism have to neurotypical peers and social environments. The purpose of this study was to investigate the effect of using a stimulus control transfer procedure on the acquisition of spontaneous mands. Four school-aged children with autism, two boys and two girls, participated in the study. A multiple baseline design across participants was utilized to demonstrate a functional relation between the stimulus control transfer procedures and the rate of spontaneous mands. Measurement variables included the frequency of spontaneous versus multiply-controlled mands during discrete trial training on a variety of verbal operants. Effectiveness of the intervention was analyzed through visual analysis and the magnitude of effect was assessed through effect size. Visual analysis indicated that three of the four participants learned to spontaneously mand for items out of view and demonstrated generalization across targets, staff and environments. The effect size for three participants were large (d = 1.94; d = 2.2; and d = 1.4), whereas the outcome of intervention for one participant (d = 0.98) indicated moderate effect. The overall (d = 1.15) outcome demonstrated a large effect of the intervention on the rate of mands. Based on the results of this study, it is recommended that early and intensive behavior intervention programs for children with autism incorporate this type of procedure for socially significant outcomes.