In this thesis closed-loop control strategies over a communication network with multiple clients are developed. To accomplish this objective, a steel-ball magnetic-levitation system, a DC motor speed-control system, and an autonomous wheelchair robot referred to as Clients 1, 2, and 3, respectively were used as Networked-Based-control (NCS) test beds to validate the proposed strategies. For real-time operation, Linux with Real-Time Application Interface (RTAI) and Control and Measurement Interface (Comedi) were used as the operating system for Clients 1 and 2. Client 3's software was written in Microsoft Visual Basic 6.0 on the Windows XP operating system (OS). User datagram protocol (UDP) was used as the communication network protocol in this research due to its better real-time performance instead of transmission control protocol (TCP). Although UDP has no guarantee for transferring data, it has smaller overheads and less time delay than TCP. Since the robotic wheelchair and the server are run on different OSs, Samba was used to put both systems into the same LAN with a fast data-transmission speed. Using Samba, the round-trip communication time between the robotic wheelchair and the server is only 11.2 ms whereas 30.8 ms is taken without using Samba. When the server receives the sensor data from multiple clients at the same time, the NCS stability may be deteriorated due to the limitation of the system bandwidth. The NCS stability is affected by the sampling period of the system, and the reduction of the sampling period improves the control loop's performance. However, a shorter sampling period requires more network bandwidth to transmit more sensor data or control data, which increases the network traffic load. Using the PING test, the transmission time for each control loop was measured. The processing time for each system was also measured by a time-stamp function, and the operation time for each control loop was obtained. In order to maintain the NCS stable, several combinations of the sampling periods for each client are suggested and verified. The bandwidth utilization of Client 1 is set to be 43.5% and the range of the bandwidth utilization of Client 2 with guaranteed stability was found to be between 9.1% and 45.3%. Thus, the bandwidth utilization of Client 3 is from 11.8% to 46.8%. The multiple-client NCS test bed could maintain its stability within these ranges of the bandwidth utilizations of all clients.

Bi-layered materials are a reduced weight derivative of the sandwich structure and are comprised of one thin skin face reinforced by a thick layer of low density material. Bi-layered materials are characterized by high flexural stiffness and are a viable alternative to conventional sandwich materials in applications where the functional requirements can be met without the second face sheet of the sandwich. For structural applications bi-layered materials are required to have oil canning and buckling resistance. This work addresses the buckling of shallow bi-layered arches using numerical and analytical approaches. A numerical, finite element model is developed to simulate the buckling phenomenon and the results were compared with known experimental data. An analytical model was developed using the energy method analysis and the buckling load was predicted from the minimum energy criterion. Comparison of the numerical and analytical results yielded fairly good agreement. An imperfection analysis conducted by means of the numerical model indicated that the load carrying capacity of bi-layered structures is reduced by up to 40% due to the presence of material and geometric imperfections. A parametric study conducted using the analytical model has been described to setup design guidelines for shallow bi-layered arches. It was found that the use of bi-layered structures can result in weight reduction of around 70% when compared with equivalent single layered structure.

A number of movements produced in everyday life require not only coordination of joints within a limb, but also coordination between one or more limbs. The aim of this dissertation was to examine the influence of biomechanical constraints on intralimb coordination, interlimb coordination, and learning. Experiment 1 sought to determine if principles of the Leading Joint Hypothesis, when applied to a multijoint bimanual coordination task, could provide insight into the contribution of intralimb dynamics to interlimb coordination. Participants repetitively traced ellipse templates in an asymmetrical coordination pattern (i.e. both limbs moving counter-clockwise). Kinematic data of the upper limbs were recorded with a VICON camera system. Ellipse templates were oriented either tilted right or tilted left; yielding a total of four left arm-right arm leading joint combinations. The findings indicated that stability of interlimb coordination patterns were found to be influenced by whether arm movements were produced with similar or different leading joints. Bimanual asymmetric ellipse-tracing produced with similar leading joints were more stable than patterns produced with different leading joints. For example, asymmetric coordination patterns produced with similar leading joints exhibited less transient behavior than coordination patterns produced with different leading joints (p < .01). Experiment 2 expanded on these findings by employing a similar task and incorporating a learning component to assess how intralimb dynamics are tuned with practice of a novel coordination pattern. Participants were randomly assigned to one of three groups. One group practiced tracing a pair of ellipse templates that were oriented in such a way that required similar leading joints while the other two groups practiced tracing ellipse templates that required different leading joints. Early in practice, the group learning the coordination pattern with similar leading joints exhibited greater interlimb stability than the two groups learning with different leading joints. However, following two days of practice, performance of the groups learning with different leading joints improved to match that of the group learning with similar leading joints. The findings suggest that initial biomechanical constraints can be overcome with practice, resulting in similar performance regardless of whether being produced with similar or different leading joints.

Abstract¡G Tumor susceptibility gene 101, TSG101, is a protein exhibits multiple biological functions. For most protein, its specific function or structure stability can be regulated through protein phosphorylation or modification. The analysis of the amino acid sequence of TSG101 revealed that it has two GSK-3£] phosphorylation concensus sequences. Our previous data of in vitro kinase assay have demonstrated that TSG101 can be phosphorylated by GSK-3£], a wellknown protein kinase that regulates the stability and function of it¡¦s target protein. To investigate the effect of GSK-3£] phosphorylation on the stability and the function of TSG101 protein, we first exploited the effect of GSK-3£]inhibitor, LiCl, on endogenous TSG101 protein in COS1 cells. The results suggested that inhibition of GSK-3£] phosphorylation could impact on the stability of TSG101 protein. Upon the transfection of an active form GSK-3£] expression plasmid GSK-3£]/pEGFP, additional protein products of 40, 50-80 kD were detected, suggesting that GSK-3£] phosphorylation might induce modification or degradation of TSG101 protein. GSK-3£] phosphorylation site mutant TSG101 protein expression plasmids were constructed using site-directed mutagenesis, and were transfected into COS1 cells to evaluate the effect of GSK-3£] on TSG101 level. The results showed that GSK-3£] phosphorylation site mutant TSG101 protein is more stable then wild type TSG101 due to the lack of GSK-3£] phosphorylation site. The inhibition of GSK-3£] activity by LiCl treatment resulted in the increase of wildtype as well as the S172AS176 and S172AS176AS202AS206A mutant TSG101 proteins, whereas the S202AS206A mutant TSG101 protein level was not affected by LiCl treatment. The above data indicated that GSK-3£] might regulate the stability and biological activity of TSG101 protein through phosphorylation of serine residue at position 202, which is worthy of further investigation.

This dissertation presents an experimental and theoretical study of subsynchronous rotordynamic instability in rotors caused by interference and shrink fit interfaces. The experimental studies show the presence of strong unstable subsynchronous vibrations in two different rotor setups with interference and shrink fit interfaces that were operated above their first critical speeds. The unstable vibrations occur at the first natural frequency of the rotor-bearing system. The instability caused complete wreckage of the test rig in one of the setups showing that these vibrations are potentially dangerous to the safe operation of rotating machines. The two different rotor setups that are studied are a single-disk rotor mounted on a uniform diameter shaft and a two-disk rotor with an aluminum sleeve shrink fitted to it at the outer surface of the two disks. In the single-disk rotor, an adjustable interference arrangement between the disk and the shaft is obtained through a tapered sleeve arrangement, which acts as the interference fit joint. The unstable sub-synchronous vibrations originate from slippage in the shrink fit and the interference fit interfaces that develop friction forces, which act as destabilizing cross-coupled moments when the rotor is operated above its first critical speed. The unique contribution offered through this work is the experimental validation of a physically correct model of internal friction which models the destabilizing mechanism as a system of cross-coupled internal moments at the shrink fit interface. The dissertation describes stability simulations of various test rotor setups using the correct internal moments model. A commercial finite-element based software called XLTRCTM is used to perform rotordynamic simulations for stability studies. The method of stability study is the computation of eigenvalues of the rotor-bearing system. A negative real part of the eigenvalue indicates instability. The simulations include the test rotors that were experimentally observed as stable and unstable with shrink and interference fit interfaces in their assemblies. The dissertation also describes the simulations of various imagined rotor configurations with shrink fit interfaces, and seeks to explain how configurations differ on rotordynamic stability depending upon several rotor-bearing parameters such as geometry and elastic properties, as well as upon the amount of internal friction parameters, which differ from configuration to configuration.

Thesis (M.S. in Mechanical Engineering)--Naval Postgraduate School, December 2003. / Thesis by Martin G. Sarch. Includes bibliographical references. Available online at two web addresses.

Thesis (M.S. in Mechanical Engineering)--Naval Postgraduate School, December 2003. / Thesis advisor(s): Fotis A. Papoulias, Charles N. Calvano. Includes bibliographical references (p. 111-112). Also available online.

Mental illness is today the leading cause of long-term sick leave and insomnia, anxiety, depression and burnout are among the most common conditions. The aim of the study was to investigate the stability of these conditions and how this is influenced by gender and age, as well as the extent to which these states are risk factors for each other. The participants were a random sample (n = 2336) from the general population in the age of 18-79 years. The results showed that stable illness was more common among women than men, and that stable illness decreased with aging. The stability itself was not affected by gender or age. Relations between the conditions were bidirectional and they constitute major risk factors for each other (odds ratios, OK = 2.37 to 6.46). The largest risk factor for a condition is, however, previous occurrence of the same problem. Previous burnout was found to be a significantly larger risk factor for future burnout than previous insomnia for future insomnia (OK = 9.63 and 5.74, respectively). The results suggest that insomnia, anxiety, depression and burnout, despite their differences, are similar regarding symptoms and underlying causes. The importance of early interventions to prevent comorbid conditions which are more complicated and more difficult to treat is emphasized. / Miljöhälsostudien i Västerbotten

With the discovery of a particle consistent with the Standard Model (SM) Higgs at the Large Hadron Collider (LHC) at CERN in 2012, the final ingredient of the SM has been found. The SM provides us with a powerful description of the physics of fundamental particles, holding up at all energy scales we can probe with accelerator based experiments. However, astrophysics and cosmology show us that the SM is not the final answer, but e.g. fails to describe dark matter and massive neutrinos. Like any non-trivial quantum field theory, the SM must be subject to a so-called renormalization procedure in order to extrapolate the model between different energy scales. In this context, new problems of more theoretical nature arise, e.g. the famous hierarchy problem of the Higgs mass. Renormalization also leads to what is known as the metastability problem of the SM: assuming the particle found at the LHC is the SM Higgs boson, the potential develops a second minimum deeper than the electroweak one in which we live, at energy scales below the Planck scale. Absolute stability all the way up to the Planck scale is excluded at a confidence level of about 98 %. For the central experimental SM values the instability occurs at scales larger than ~ 10¹⁰ GeV. One can take two viewpoints regarding this instability: assuming validity of the SM all the way up to the Planck scale, the problem does not necessarily lead to an inconsistency of our existence. If we assume our universe to have ended up in the electroweak minimum after the Big Bang, the probability that it would have transitioned to its true minimum during the lifetime of the universe is spectacularly small.  If we on the other hand demand absolute stability, new physics must modify the SM at or below the instability scale of ~ 10¹⁰ GeV, and we can explore which hints the instability might provide us with on this new physics. In this work, the metastability problem of the SM and possible implications are revisited. We give an introduction to the technique of renormalization and apply this to the SM. We then discuss the stability of the SM potential and the hints this might provide us with on new physics at large scales. / Standardmodellen inom partikelfysik är vår bästa beskrivning av elementarpartiklarnas fysik. År 2012 hittades en ny skalär boson vid Large Hadron Collider (LHC) på CERN, som är kompatibel med att vara Higgs bosonen, den sista saknade delen av Standardmodellen. Men även om Standardmodellen ger oss en väldigt precis beskrivning av all fysik vi ser i partikelacceleratorer, vet vi från astropartikelfysik och kosmologi att den inte kan vara hela lösningen. T.ex. beskriver Standardmodellen ej mörk materia eller neutrinernas massa. Som alla kvantfältteorier måste man renormera Standardmodellen för att få en beskrivning som fungerar på olika energiskalor. När man renormerar Standardmodellen hittar man nya problem som är mer teoretiska, t.ex. det välkända hierarkiproblemet av Higgsmassan. Renormering leder också till vad som kallas för metastabilitetsproblemet, dvs att Higgspotentialen utvecklar ett minimum som är djupare än det elektrosvaga minimum vi lever i, på högre energiskalor. Om vi antar att partikeln som hittades på CERN är Standardmodellens Higgs boson, är absolut stabilitet exkluderad med 98 % konfidens. För centrala experimentiella mätningar av Standardmodells parametrar uppkommer instabiliteten på skalor över ~ 10¹⁰ GeV. Det finns två olika sätt att tolka stabilitetsproblemet: Om man antar att Standardmodellen är den rätta teorien ända upp till Planckskalan, kan vi faktiskt fortfarande existera. Om vi antar att universum hamnat i det elektrosvaga minimumet efter Big Bang är sannolikheten att det har gått över till sitt riktiga minimum under universums livstid praktiskt taget noll. Dvs att vi kan leva i ett metastabilt universum. Om vi å andra sidan kräver att potentialen måste vara absolut stabil, måste någon ny fysik modifiera Standardmodellen på eller under instabilitetsskalan ~10¹⁰ GeV. I så fall kan vi fundera på vilka antydningar stabilitetsproblemet kan ge oss om den nya fysiken. Den här uppsatsen beskriver Standardmodells metastabilitetsproblem. Vi ger en introduktion till renormering och använder tekniken till Standardmodellen. Sen diskuteras stabiliteten inom Standardmodellens potential och vilka antydningar problemet kan ge oss angående ny fysik.

Three-dimensional integrated circuits (3D-IC) have emerged as promising candidates to overcome the interconnect bottlenecks of nanometer scale designs while also helping to reduce wire delay and increase memory throughput. While this technology offers many potential advantages, it also produces large thermal mismatch stress in 3D-IC structures employing Through-Silicon-Via (TSV). The stress distribution in silicon and interconnect is affected by the via diameter and layout geometry. TSV-induced stress effects on electron/hole mobility and device performance will be studied for the widely used 6-transistor (6T) SRAM cell. Simulation results in this study show that static noise margin (SNM), Read Margin (RM) and write margin (WM) tend to increase with decreasing electron mobility or increasing hole mobility. Considering TSV-induced stress, we propose that for practical layouts of TSV-based 3D-IC, p-type substrates should be placed further away from TSVs or closer to the smaller TSVs if multiple TSVs exist. / text