Yes / In this study, the enhancement of stainless steel wires (SSWs) to the flexural fatigue performance of reactive powder concrete (RPC) including fatigue life and fatigue stress-strain hysteresis relationship as well as fatigue damage were investigated, and the underlying mechanisms were explored through microstructure observation and characteristic analyses of hydration products. The average flexural fatigue life of RPC is increased by 636.6%, 558.3% and 1010.7% at the maximum stress levels of 0.7, 0.8 and 0.9 when 1.5 vol.% SSWs are incorporated. The method of moments and method of maximum likelihood are employed to calculate the scale and shape parameters for fatigue life subscribed to Weibull distribution. The calculated ratio of flexural fatigue endurance limit to static flexural strength for SSWs reinforced RPC reaches up to 0.64. The incorporation of SSWs decreases the flexural failure damage of RPC by 41.5% and converts the long and link-up micro cracks into emission cracks centered on SSWs. Benefited from the large specific surface area of SSWs, abound of silica fume with pozzolanic activity absorbs on the surface of SSWs and continues to hydrate, reducing the surrounding water-binder ratio to form a microstructure enhancement zone with SSWs as the core and improve the homogeneity of RPC. This can be confirmed by the decrease of porosity, Ca(OH)2 crystal orientation index and molar ratio of CaO to SiO2 for calcium silicate hydrate gels. SSWs can also enhance the fatigue performance of RPC by transmitting hydration heat, inhibiting the initiation and propagation of micro cracks especially at the initial stage of fatigue load, bridging cracks and being pulled-off. The excellent flexural fatigue properties and homogeneous microstructures of SSWs reinforced RPC make it particularly suitable for large-span and ultra-thin elements in extreme service environments.