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Thesis (Ph. D.)--University of Wisconsin, 1965. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

Staphylococcal tenosynovitis and osteomyelitis are world-wide problems of broilers and broiler breeders caused by staphylococci. Pathogenesis of the disease is ill defined. Avian heterophils are analogous to mammalian neutrophils but the granules appear to be different. The first chemotactic study was done on heterophils from chickens having natural staphylococcal infection brought from a commercial broiler flock and on the heterophils obtained from healthy 6-8 weeks old chickens brought from a local hatchery as one day old chicks. In the second study, a chemotactic study was done with three different staphylococci on heterophils obtained from healthy 6-8 weeks old chickens brought from a local hatchery as one day old chicks. Results for the first study showed a decreased chemotactic response in the heterophils of chickens naturally infected with staphylococcus compared to healthy chicken heterophils in response to minimum essential medium, pooled normal chicken serum and E. coli endotoxin with normal chicken serum used as chemoattractants. Second study results showed that pathogenic capsule type 5 and type 8 Staphylococcus aureus isolates both induced chemotaxis in heterophils from healthy chickens to a significantly greater degree than did a non-pathogenic Staphylococcus xylosus. The Staphylococcus aureus isolate with capsule type 5 induced heterophil chemotaxis more than the capsule type 8 isolate. / Graduation date: 1993

Thesis (Ph. D.)--University of Sydney, 2000. / Title from title screen (viewed Apr. 21, 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Faculty of Dentistry. Degree awarded 2000; thesis submitted 1999. Includes bibliographical references. Also available in print form.

Some strains of coagulase-negative staphylococci produce an extracellular material, slime, which mediates adherence to foreign surfaces, such as indwelling biomedical devices. It is not known if slime is involved in adherence to human tissue. Coagulase-negative staphylococci are the most common members of normal ocular flora and cause many ocular infections, although the role of slime in these infections has not been studied.

Gram-positive pathogens are responsible for a wide range of global diseases, including nosocomial infections. The increasing incidence of antibiotic-resistant strains warrants the development of novel therapeutic strategies to combat these organisms.

Call number: LD2668 .T4 1959 P36

Doctor of Philosophy / This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Doctor of Philosophy / This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au