published_or_final_version / abstract / Electrical and Electronic Engineering / Doctoral / Doctor of Philosophy

published_or_final_version / Electrical and Electronic Engineering / Master / Master of Philosophy

published_or_final_version / Business / Master / Master of Philosophy

Conventional imaging techniques for cancer detection have difficulty finding small, deep tumors. Single-detector radiation probes have been developed to search for deep lesions in a patient who has been given a tumor-seeking radiopharmaceutical. These probes perform poorly, however, when the background activity in the patient varies greatly from site to site. We have developed a surgical dual-detector probe that solves the problem of background activity variation, by simultaneously monitoring counts from a region of interest and counts from adjacent normal tissue. A comparison of counts from the detectors can reveal the class of tissue, tumor or normal, in the region of interest. In this dissertation we apply methods from statistical decision theory and derive a suitable comparison of counts to help us decide whether a tumor is present in the region of interest. We use the Hotelling trace criterion with a few assumptions to find a linear discriminant function, which can be reduced to a normalized subtraction of the counts for large background count-rate variations. If area under the ROC curve is our figure of merit, the likelihood ratio is the optimum discriminant. We model likelihood functions of the data given the "tumor" and "no-tumor" hypotheses, and calculate the likelihood ratio. Using a spatial response map of the dual probe, a computer torso phantom, and estimates of activity distribution, we simulate a surgical staging procedure to test the dual probe and the discriminant functions. Results of the simulations show that the dual probe effectively solves the problem of background activity variations when used with any of the discriminant functions derived in this dissertation.

Ph.D. / This thesis investigates the persistence of hedge fund managers’ skills, the optimality of strategies they use to outperform consistently the market during periods of boom and/or recession, and the market risk encountered thereby. We consider a data set of monthly investment strategy indices published by Hedge Fund Research group. The data set spans from January 1995 to June 2010. We divide this sample period into four overlapping sub- sample periods that contain different economic market trends. We define a skilled manager as a manager who can outperform the market consistently during two consecutive sub-sample periods. To investigate the presence of managerial skills among hedge fund managers we first distinguish between outperformance, selectivity and market timing skills. We thereafter employ three different econometric models: frequentist, Bayesian and fuzzy regression, in order to estimate outperformance, selectivity and market timing skills using both linear and quadratic CAPM. Persistence in performance is carried out in three different fashions: contingence table, chi-square test and cross-sectional auto-regression technique. The results obtained with the first two probabilistic methods (frequentist and Bayesian) show that fund managers have skills to outperform the market during the period of positive economic growth (i.e. between sub-sample period 1 and sub-sample period 3). This market outperformance is due to both selectivity skill (during sub-sample period 2 and sub-sample period 3), and market timing skill (during sub-sample period 1 and sub- sample period 2). These results contradict the EMH and suggest that the “market is not always efficient,” it is possible to make abnormal rate of returns.However, the results obtained with the uncertainty fuzzy credibility method show that dispite the presence of few fund managers who possess selectivity skills during bull market period (sub-sample period 2 and sub-sample period 3), and market timing skills during recovery period (sub-sample period 3 and sub-sample period 4); there is no evidence of overall market outperformance during the entire sample period. Therefore the fuzzy credibility results support the appeal of the EMH according to which no economic agent can make risk-adjusted abnormal rate of return. The difference in findings obtained with the probabilistic method (frequentist and Bayesian) and uncertainty method (fuzzy credibility theory) is primarily due to the way uncertainty is modelled in the hedge fund universe in particular and in financial markets in general. Probability differs fundamentally from uncertainty: probability assumes that the total number of states of economy is known, whereas uncertainty assumes that the total number of states of economy is unknown. Furthermore, probabilistic methods rely on the assumption that asset returns are normally distributed and that transaction costs are negligible.

A research report submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of' Science. / This research report describes the use or the Pearl's algorithm in Bayesian belief networks to induce a belief network from a database. With a solid grounding in probability theory, the Pearl algorithm allows belief updating by propagating likelihoods of leaf nodes (variables) and the prior probabilities. The Pearl algorithm was originally developed for binary variables and a generalization to more states is investigated. The data 'Used to test this new method, in a Portfolio Management context, are the Return and various attributes of companies listed on the Johannesburg Stock Exchange ( JSE ). The results of this model is then compared to a linear regression model. The bayesian method is found to perform better than a linear regression approach. / Andrew Chakane 2018

Analyzing life-time data with long-term survivors is an important topic in medical application. Cure models are usually used to analyze survival data with the proportion of cure subjects or long-term survivors. In order to include the propor- tion of cure subjects, mixture and non-mixture cure models are considered. In this dissertation, we utilize both maximum likelihood and Bayesian methods to estimate model parameters. Simulation studies are carried out to verify the nite sample per- formance of the estimation methods. Real data analyses are reported to illustrate the goodness-of- t via Fr echet, Weibull and Exponentiated Exponential susceptible distributions. Among the three parametric susceptible distributions, Fr echet is the most promising. Next, we extend the non-mixture cure model to include a change point in a covariate for right censored data. The smoothed likelihood approach is used to address the problem of a log-likelihood function which is not di erentiable with respect to the change point. The simulation study is based on the non-mixture change point cure model with an exponential distribution for the susceptible subjects. The simulation results revealed a convincing performance of the proposed method of estimation. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection

This thesis contains two parts. The first part derives the Bayesian estimator of the parameters in a piecewise exponential Cox proportional hazard regression model, with one unknown change point for a right censored survival data. The second part surveys the applications of change point problems to various types of data, such as long-term survival data, longitudinal data and time series data. Furthermore, the proposed method is then used to analyse a real survival data. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2014. / FAU Electronic Theses and Dissertations Collection

Keywords: MCEM algorithm; Gibbs sampler; Multivariate probit model; Multi-group; BIC. / The main purpose of this paper is to develop maximum likelihood and Bayesian approach for the multivariate probit model in several populations. A Monte Carlo EM algorithm is proposed for obtaining the maximum likelihood estimates and the Gibbs sampler is used to produce the joint Bayesian estimates. To test hypotheses involving constraints among the structural parameters of MP model across groups, we use the method of Bayesian Information Criterion(BIC). The simulation study will be given to certify the accuracy of our algorithm. / Yu, Yin. / "March 2007." / Adviser: Sik Yum Lee. / Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6054. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2007. / Includes bibliographical references (p. 135-137). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract in English and Chinese. / School code: 1307.

By the Bayesian decision theoretical view, we propose several extensions of current popular graph based methods. Several data-dependent graph construction approaches are proposed by adopting more flexible density estimators. The advantage of these approaches is that the parameters for constructing the graph can be estimated from the data. The constructed graph explores the intrinsic distribution of the data. As a result, the algorithm is more robust. It can obtain good performance constantly across different data sets. Using the flexible density models can result in directed graphs which cannot be handled by traditional graph partitioning algorithms. To tackle this problem, we propose general algorithms for graph partitioning, which can deal with both undirected and directed graphs in a unified way. / In this thesis, we establish a novel probabilistic framework for the data clustering problem from the perspective of Bayesian decision theory. The Bayesian decision theory view justifies the important questions: what is a cluster and what a clustering algorithm should optimize. / We prove that the spectral clustering (to be specific, the normalized cut) algorithm can be derived from this framework. Especially, it can be shown that the normalized cut is a nonparametric clustering method which adopts a kernel density estimator as its density model and tries to minimize the expected classification error or Bayes risk. / Chen, Mo. / Adviser: Xiaoou Tang. / Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 96-104). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.