This research provides quantitative data to aid engineers in the selection of various attributes to facilitate fit-up during I-girder bridge construction. Concepts and procedures for explicit calculation of locked-in forces due to cross-frame detailing are developed and discussed. Fit-up forces are evaluated and discussed for a suite of bridge cases analyzed in this research. Bridge cases with difficult fit-up are highlighted. Recommendations for erection procedures are provided to facilitate fit-up. The research investigates and recommends beneficial staggered cross-frame framing arrangements that are applicable to straight skewed bridges, framing arrangements with liberal offsets around bearing lines at interior pier in continuous spans bridges, and the use of staggered versus lean-on cross-frame arrangements in straight skewed bridges. The research also addresses the impacts of cross-frame detailing methods, that is, the “fit condition” of the structure, on cross-frame forces, girder elevations, girder layovers, girder stresses, and vertical reactions in the completed bridges.