A global/local framework for multidisciplinary optimization of generalized aircraft wing structure has been developed. The concept of curvilinear stiffening members (spars, ribs and stiffeners) has been applied in the optimization of a wing structure. A global wing optimization framework EBF3WingOpt, which integrates the static aeroelastic, flutter and buckling analysis, has been implemented for exploiting the optimal design at the wing level. The wing internal structure is optimized using curvilinear spars and ribs (SpaRibs). A two-step optimization approach, which consists of topology optimization with shape design variables and size optimization with thickness design variables, is implemented in EBF3WingOpt. A local panel optimization EBF3PanelOpt, which includes stress and buckling evaluation criteria, is performed to optimize the local panels bordered by spars and ribs for further structural weight saving. The local panel model is extracted from the global finite element model. The boundary conditions are defined on the edges of local panels using the displacement fields obtained from the global model analysis. The local panels are optimized to satisfy stress and buckling constraints. Stiffened panel with curvilinear stiffeners is implemented in EBF3PanelOpt to improve the buckling resistance of the local panels. The optimization of stiffened panels has been studied and integrated in the local panel optimization. EBF3WingOpt has been applied for the optimization of the wing structure of the Boeing N+2 supersonic transport wing and NASA common research model (CRM). The optimization results have shown the advantage of curvilinear spars and ribs concept. The local panel optimization EBF3PanelOpt is performed for the NASA CRM wing. The global-local optimization framework EBF3GLWingOpt, which incorporates global wing optimization module EBF3WingOpt and local panel optimization module EBF3PanelOpt, is developed using MATLAB and Python programming to integrate several commercial software: MSC.PATRAN for pre and post processing, MSC.NASTRAN for finite element analysis. An approximate optimization method is developed for the stiffened panel optimization so as to reduce the computational cost. The integrated global-local optimization approach has been applied to subsonic NASA common research model (CRM) wing which proves the methodology's application scaling with medium fidelity FEM analysis. Both the global wing design variables and local panel design variables are optimized to minimize the wing weight at an acceptable computational cost. / Ph. D.