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Considerations in the practical implementation of a travelling wave cochlear implant processorDu Preez, Christiaan Cronje 10 August 2012 (has links)
Speech processing in the human cochlea introduces travelling waves on the basilar membrane.
These travelling waves have largely been ignored in most processing strategies. This
study implements a hydrodynamical model in a speech processing strategy in order to investigate
the neural spike train patterns for a travelling wave processing strategy. In cochlear implants
a trade-off remains between the simulation rate and the number of electrode channels.
This trade-off was investigated in the proposed travelling wave strategy. Taking into consideration
existing current spread and electrical stimulation models, predicted neural spike train
responses have shown that stimulating fewer channels (six and four) at stimulation rates of
2 400 pps and 3 600 pps gives better approximations of predicted normal hearing responses
for input frequencies of 200 Hz, 600 Hz and 1 kHz, compared to stimulating more channels at lower channel stimulation rates. The predicted neural spike train patterns suggest
that these resulting neural patterns might contain both spatial and temporal information that
could be extracted by the auditory system. For a frequency of 4 kHz the predicted neural
patterns for a channel-number stimulation-rate configuration of 2 - 7 200 pps suggested that
although there is no travelling wave delay information, the predicted neural patterns still contain
temporal information. The predicted ISI histograms show peaks at the input tone period
and multiples thereof, with clusters of spikes evident around the tone period in the predicted
spatio-temporal neural spike train patterns. Similar peaks at the tone period were observed
for calculated ISI histograms for predicted normal hearing neural patterns and measured neural
responses. The predicted spatio-temporal neural patterns for the input frequency of 200
Hz show the travelling wave delay with clusters of spikes at the tone period. This travelling
wave delay can also be seen from predicted normal hearing neural responses. The current
spread, however, shows a significant distortion effect around the characteristic frequency
place where the travelling wave delay increases rapidly. Spacing electrodes more closely
results in an increase in this distortion, with the nerve fibre threshold decreasing in adjacent
populations of nerve fibres, increasing the probability of firing. The current spread showed a
more limited distortion effect on travelling wave delays when electrodes were spaced across
the cochlea, at an electrode spacing of 6.08 mm. ISI histogram results also showed increased
peaks around the tone period and multiples thereof. These predicted neural spike train patterns
suggest that travelling waves in processing strategies, although mostly ignored, might
provide the auditory system with both the spatial and temporal information needed for better
pitch perception. / Dissertation (MEng)--University of Pretoria, 2012. / Electrical, Electronic and Computer Engineering / MEng / Unrestricted
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Einfluss chronischer elektrischer intracochleärer Stimulation auf das zentrale und periphere auditorische System im Meerschweinchen (Cavia porcellus)Jansen, Sebastian 28 November 2016 (has links)
In der vorliegenden Arbeit wurden einseitig mit Human-Cochlea-Implantat versorgte Meerschweinchen verwendet, die auf dem anderen Ohr normalhörend waren und mit einer einseitig vertäubten, aber nicht elektrostimulierten Kontrollgruppe verglichen wurden. Untersucht wurde der Einfluss von drei unterschiedlichen Stimulationsraten und drei Stimulationsintensitäten während einer einseitigen Elektrostimulation. Dabei wurde zunächst der Einfluss der Elektrostimulation auf die Hörschwellen mittels Hirnstammaudiometrie (ABR) untersucht. Anschließend wurden die Zelldichten in der aufsteigenden Hörbahn (dorsaler Nucleus Cochlearis, Colliculus Inferior, medialer Kniehöcker und auditorischer Cortex) im Hirnschnitt unter Verwendung einer Hämalaun-Eosin Färbung bestimmt. Ein Zusammenhang zwischen der verwendeten Stimulationsrate und den in der zentralen Hörbahn gefundenen Zelldichten wurde ebenso wenig gezeigt wie ein Zusammenhang mit den mittels ABR ermittelten Hörschwellen der normalhörenden Seite. Dagegen wurde jedoch ein Zusammenhang zwischen den in der Elektrostimulation verwendeten Stimulationsintensitäten und den ermittelten Zelldichten festgestellt. Die niedrigste verwendete Stimulationsintensität führte zu einer bilateralen Konservierung der Zelldichten in der gesamten untersuchten Hörbahn, wogegen eine Elektrostimulation mit der höchsten Stimulationsintensität zum Teil einen bilateralen Zellverlust im dorsalen Nucleus Cochlearis, medialen Kniehöcker und im auditorischen Cortex zur Folge hatte. Dieser Zellverlust führte in dem Untersuchungszeitraum nicht zu einer signifikanten Veränderung der Hörschwelle. / In this study, human cochlear implants (CI) were implanted unilaterally in the cochlea of guinea pigs that were normal hearing on the contralateral side. Electro-stimulation was used on the cochlea with the implanted CI. They were compared to an unilaterally implanted but not electro-stimulated control group. This study investigates the effect of three different stimulation-rates and three different stimulation-intensities in unilateral electro-stimulation. The effect of the electro-stimulation on the hearing thresholds was determined using auditory brainstem recordings (ABR). Afterwards, cell densities in the ascending auditory pathway (dorsal cochlear nucleus, inferior colliculus, medial geniculate body and auditory cortex) were measured in brain slices stained with hematoxylin and eosin. No evidence was found of a connection between the different stimulation rates of electro-stimulation in the cochlea with a CI and cell densities seen in the central auditory pathway. Furthermore, there were no links found between hearing thresholds determined by ABR and the different parameters that were used for the electro-stimulation. However a significant effect of the different stimulation intensities on the cell densities identified in the auditory pathway was demonstrated. The lowest intensity used in the electro stimulation led to a bilateral preservation of cell densities in the entire auditory pathway whereas electro-stimulation with the highest intensity induced a significant cell loss in the auditory pathway (dorsal cochlear nucleus, the medial geniculate body and the auditory cortex). Interestingly, this cell loss was not accompanied by significant changes in the auditory threshold.
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