Threat assessment and reliable motion-prediction of surrounding vehicles are some of the major challenges encountered in autonomous vehicles' safe decision-making. Predicting a threat in advance can give an autonomous vehicle enough time to avoid crashes or near crash situations. Most vehicles on roads are human-driven, making it challenging to predict their intentions and movements due to inherent uncertainty in their behaviors. Moreover, different driver behaviors pose different kinds of threats. Various driver behavior predictive models have been proposed in the literature for motion prediction. However, these models cannot be trusted entirely due to the human drivers' highly uncertain nature. This thesis proposes a novel trust-based driver behavior prediction and stochastic reachable set threat assessment methodology for various dangerous situations on the road. This trust-based methodology allows autonomous vehicles to quantify the degree of trust in their predictions to generate the probabilistically safest trajectory. This approach can be instrumental in the near-crash scenarios where no collision-free trajectory exists. Three different driving behaviors are considered: Normal, Aggressive, and Drowsy. Hidden Markov Models are used for driver behavior prediction. A "trust" in the detected driver is established by combining four driving features: Longitudinal acceleration, lateral acceleration, lane deviation, and velocity. A stochastic reachable set-based approach is used to model these three different driving behaviors. Two measures of threat are proposed: Current Threat and Short Term Prediction Threat which quantify present and the future probability of a crash. The proposed threat assessment methodology resulted in a lower rate of false positives and negatives. This probabilistic threat assessment methodology is used to address the second challenge in autonomous vehicle safety: crash avoidance decision-making. This thesis presents a fast, proactive decision-making methodology based on Stochastic Model Predictive Control (SMPC). A proactive decision-making approach exploits the surrounding human-driven vehicles' intent to assess the future threat, which helps generate a safe trajectory in advance, unlike reactive decision-making approaches that do not account for the surrounding vehicles' future intent. The crash avoidance problem is formulated as a chance-constrained optimization problem to account for uncertainty in the surrounding vehicle's motion. These chance-constraints always ensure a minimum probabilistic safety of the autonomous vehicle by keeping the probability of crash below a predefined risk parameter. This thesis proposes a tractable and deterministic reformulation of these chance-constraints using convex hull formulation for a fast real-time implementation. The controller's performance is studied for different risk parameters used in the chance-constraint formulation. Simulation results show that the proposed control methodology can avoid crashes in most hazardous situations on the road. / Master of Science / Unexpected road situations frequently arise on the roads which leads to crashes. In an NHTSA study, it was reported that around 94% of car crashes could be attributed to driver errors and misjudgments. This could be attributed to drinking and driving, fatigue, or reckless driving on the roads. Full self-driving cars can significantly reduce the frequency of such accidents. Testing of self-driving cars has recently begun on certain roads, and it is estimated that one in ten cars will be self-driving by the year 2030. This means that these self-driving cars will need to operate in human-driven environments and interact with human-driven vehicles. Therefore, it is crucial for autonomous vehicles to understand the way humans drive on the road to avoid collisions and interact safely with human-driven vehicles on the road. Detecting a threat in advance and generating a safe trajectory for crash avoidance are some of the major challenges faced by autonomous vehicles. We have proposed a reliable decision-making algorithm for crash avoidance in autonomous vehicles. Our framework addresses two core challenges encountered in crash avoidance decision-making in autonomous vehicles: 1. The outside challenge: Reliable motion prediction of surrounding vehicles to continuously assess the threat to the autonomous vehicle. 2. The inside challenge: Generating a safe trajectory for the autonomous vehicle in case of future predicted threat. The outside challenge is to predict the motion of surrounding vehicles. This requires building a reliable model through which future evolution of their position states can be predicted. Building these models is not trivial, as the surrounding vehicles' motion depends on human driver intentions and behaviors, which are highly uncertain. Various driver behavior predictive models have been proposed in the literature. However, most do not quantify trust in their predictions. We have proposed a trust-based driver behavior prediction method which combines all sensor measurements to output the probability (trust value) of a certain driver being "drowsy", "aggressive", or "normal". This method allows the autonomous vehicle to choose how much to trust a particular prediction. Once a picture is painted of surrounding vehicles, we can generate safe trajectories in advance – the inside challenge. Most existing approaches use stochastic optimal control methods, which are computationally expensive and impractical for fast real-time decision-making in crash scenarios. We have proposed a fast, proactive decision-making algorithm to generate crash avoidance trajectories based on Stochastic Model Predictive Control (SMPC). We reformulate the SMPC probabilistic constraints as deterministic constraints using convex hull formulation, allowing for faster real-time implementation. This deterministic SMPC implementation ensures in real-time that the vehicle maintains a minimum probabilistic safety.