The study of Stochastic Local Search (SLS) algorithms is becoming more pivotal these days, due to their vast number of applications in decision making. Prior to the implementation of algorithmic knowledge for decision making, many decisions were made based on manual calculation, on the fly, or even based on guts feeling. Nowadays, such an approach is more rarely seen, especially when the decisions that need to be made are high-risk, cost intensive, or time-consuming. The increasingly often used SLS algorithms are one of the options available to assist the decision making process these days.The work discussed in this thesis concerns the study of SLS algorithms for solving the Quadratic Assignment Problem (QAP), a prominent combinatorial optimization problem, which until today is very hard to solve. Our interest is to study the behavior and performance of SLS algorithms for solving QAP instances of different characteristics, such as size, sparsity, and structure. In this study, we have also proposed new variants of SLS algorithms, inspired by existing, well-performing SLS algorithms for solving the QAP. The new variants of SLS algorithms are then further extended for solving the bi-objective QAP (bQAP).One main focus in this study is to see how the performance of algorithms scales with instance size. We have considered instances that are much larger than the ones usually used in the studies of algorithms for solving the QAP. By understanding how the algorithms perform when the instance size changes, we might be able to solve other problems effectively by considering the similarity in their characteristics to the ones of the QAP, or by seeing common trends in the relative performance of the various available SLS methods. For single objective QAP instances we found that the structure and size of instances do have a significant impact on the performance of SLS algorithms. For example, comparisons between Tabu Search (TS) and Simulated Annealing (SA) on instances with randomly generated matrices show that the overall performance of TS is better than SA, irrespective the size of instances considered. The results on a class of structured instances however show that TS performs well on small-sized instances, while on the larger ones, SA shows better results. In another experiment, Hierarchical Iterated Local Search (HILS) has shown very good results compared to several Iterated Local Search (ILS) variants. This experiment was done on a class of structured instances of size from 100 to 500. An extensive experiment on a class of structured instances of size 30 to 300 using tuned parameter settings shows that population based algorithms perform very well on most of the instance classes considered. SA however, shows very good performance especially on large-sized instances with low sparsity level. For the bQAP, the correlation between the flow matrices does have a strong effect that determines the performance of algorithms for solving them. Hybrid Simulated Annealing (HSA) clearly outperforms Hybrid Iterative Improvement (HII). When compared to Multi Objective Ant Colony Optimization (MOACO) and Strength Pareto Evolutionary Algorithm 2 (SPEA2), HSA shows very good performance, where HSA outperforms MOACO and SPEA2, especially on instances of large size, thus, offering a better scaling behavior. Based the results obtained in this study, it is possible to come up with a general idea on the suitability of SLS algorithms for solving instances with a certain characteristic. Given an unknown QAP instance, one can guess the most suitable algorithm for solving it depending on the type, size, and sparsity of the instance, while for a bQAP instance the most suitable algorithm can be guessed based on its size and correlation between the flow matrices. / Doctorat en Sciences de l'ingénieur et technologie / info:eu-repo/semantics/nonPublished