Thesis (M.S.)--University of Wisconsin--Madison, 1957. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 81-84).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1962. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1982. / Extra t.p. with thesis statement inserted. Includes five of the author's published papers. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Wisconsin--Madison, 1981. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 60-69).

Thesis--Wisconsin. / Vita. Includes bibliographical references.

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1982. / Extra t.p. with thesis statement inserted. Includes five of the author's published papers. Includes bibliographical references.

The potential of human adenovirus (Ad) to serve as a vector for expression of heterologous genes was evaluated. An experimental gene, consisting of sequences coding for the glycoprotein of vesicular stomatitis virus (VSV) attached to the promoter and polyadenylation signal of the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) gene, was inserted into early region 3 of adenovirus, in both orientations. The TK promoter was functional in both orientations. The TK promoter was functional in both orientations and responded to trans-activation by HSV infection. Abundant expression of VSV G however depended on the presence of a second transcript. This transcript was present only in the recombinant carrying the insertion in the orientation parallel to the E3 promoter (AdG12) and was initiated upstream of the insertion, within Ad sequences. The potential of Ad recombinants to serve as vaccine vectors was investigated using the recombinant AdG12. Antibody against VSV G was induced in cows, pigs, and dogs in response to infection with AdG12. Protection of mice, immunized with AdG12, against a lethal challenge with VSV demonstrated the biological effectiveness of this immune response. / Thesis / Master of Science (MS)

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1957. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 85-90).

Made available in DSpace on 2014-06-11T19:28:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-02-27Bitstream added on 2014-06-13T20:18:31Z : No. of bitstreams: 1 davila_s_me_arafo.pdf: 393788 bytes, checksum: 2a1483d53614b48a6d0808af22f12f9d (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Embora a etiologia da estomatite por prótese total seja frequentemente associada à Candida albicans, a literatura também indica que a infecção pode ser associada à outros fatores. Neste ínterim, o objetivo deste estudo foi avaliar a correlação entre a prevalência da estomatite por prótese total, o grupo sanguíneo ABO, presença de Candida ssp. e a higienização da prótese total. Foram avaliados 30 pacienttes (média de idade de 61,13 +-11,96 anos) portadores de prótese total superior, sendo que 23 eram do sexo feminino. O exame clínico incluiu a avaliação da mucosa do palato e a avaliação da higienização da prótese total. A qualificação da higiene da prótese total foi feita por meio da visualização do biofilme com o uso de evidenciadores de placa, nas superfícies internas das próteses. As amostras micológicas foram obtidas da mucosa do palato (região central), da superfície interna da prótese total (região central) e do dorso da língua, por meio da técnica de impressão (imprint), utilizando discos de filtro de papel, colocados diretamente em placas de cultura contendo meio seletivo CHROMagar Candida. As espécies isoladas foram identificadas por meio da prova de produção de clamidoconídeo e pelo sistem API 20C AUX, além da pré-identificação fornecida pelo uso do meio seletivo. Amostra sanguínea foi coletada para determinação do tipo sanguíneo do paciente (sistema ABO e Rh). As análises estatísticas dos resultados foram feitas utilizando testes não paramétricos (Spearman, Mann-Whitney e Kruskal-Wallis). Em nosso estudo, 53,33% dos pacientes apresentaram estomatite por prótese total e a identificação de Candida ssp. foi positiva para 80% dos pacientes. O grau de higiene das próteses... / Although the etiology of denture stomatitis has been commonly related to Candida albicans, some previous studies indicate that the infection could be associated to other factors. The aim of this study was to evaluate the correlation between the prevalence of denture stomatitis, ABO blood groups, mycological status and denture cleanliness. Thirty patients with mean age of 61.13+-11.96 yeas being 23 female using complete maxillary dentures were investigated. Oral examinations included clinical diagnosis of denture stomatitis as well as the evaluation of denture cleanliness. The denture cleanliness was assessed using a stain as plaque detector in the fitting denture surface. The yeast cultures from the palatal mucosa, fitting denture surface and dorsum of the tongue were obtained using an imprint at CHROMagar Candida. The determinations of the species of the isolates was performed by chlamydospore formation and sugar assimilation using API 20C AUX. Venous blood was collected for ABO blood group determination. Spearman correlation, non-parametric t test and analysis of variance were performed to analyse the data. In this study, 53.33% of the patients presented denture stomatitis and the identification of Candida spp. was positive in 80% of the samples. The denture clean liness was classified as poor in 93.33% of the dentures. A statistical correlation was found between yeast detection and denture stomatitis (r=0.8250; p<0,0001) and between Candida ssp. and denture cleanliness (r=0,4666; p=0,0248). Although, majority of the patients were from blood group O no statistical correlation was found between clinical variables and mycological results. Candida albicans was the most frequent yeast isolated (60.94%) followed by C. tropicalis, C. glabrata... (Complete abstract, click electronic address below)