No / This study aimed to enable a cohort of women to describe their personal experiences of motherhood in the context of problematic substance use and street-based prostitution. The study also aimed to describe the impact upon women of separation from their children. Findings that emerged from focus group data were organised into four over-arching themes: children and motherhood, personal accounts of drug use and street-based prostitution, risks to women and their children and supportive/unsupportive factors in the women’s lives. Each theme consisted of many categories that illustrated the impact of dependent drug use and involvement in prostitution on the lives of the women and their children. This article describes the theme of children and motherhood. Involvement in street-based prostitution is extremely risky, frequently characterised by calculated risk taking, with consequences for both the woman and her children. Parental responsibilities and lifestyle contribute to stress, which is typically compounded by problematic substance use. Risks are increased for both the woman and her children when timely and appropriate support is unavailable. Emphasis should be placed upon the proactive identification and implementation of positive supportive strategies. Ethical approval was obtained via the Local Research Ethics Committee to undertake this research study.