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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Evolution of Streptococcus pneumoniae during carriage

Chewapreecha, Kamolchanok January 2015 (has links)
No description available.
2

Studies of the two-component signal transduction system RR/HK06 in Streptococcus pneumoniae.

Standish, Alistair James January 2006 (has links)
Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for significant morbidity and mortality worldwide. Pneumococcal disease, which can include both invasive conditions such as pneumonia, bacteremia and meningitis, as well as less severe conditions such as otitis media, is almost invariably preceded by asymptomatic colonisation of the nasopharynx. To successfully adapt to the different ecological niches it encounters, the pneumococcus is likely to rely on the co-ordinated regulation of key virulence factors. As is the case for many other prokaryotes, this is likely to occur through two-component signal transduction systems (TCSTSs). TCSTSs comprise a histidine kinase (HK) and response regulator (RR). They respond to environmental stimuli, and regulate gene expression by interacting with the transcription machinery. Thirteen complete TCSTSs have been identified in S. pneumoniae, along with a lone RR. This study focused on one of these systems, designated RR/HK06. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1255323 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2006
3

Studies of the two-component signal transduction system RR/HK06 in Streptococcus pneumoniae.

Standish, Alistair James January 2006 (has links)
Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for significant morbidity and mortality worldwide. Pneumococcal disease, which can include both invasive conditions such as pneumonia, bacteremia and meningitis, as well as less severe conditions such as otitis media, is almost invariably preceded by asymptomatic colonisation of the nasopharynx. To successfully adapt to the different ecological niches it encounters, the pneumococcus is likely to rely on the co-ordinated regulation of key virulence factors. As is the case for many other prokaryotes, this is likely to occur through two-component signal transduction systems (TCSTSs). TCSTSs comprise a histidine kinase (HK) and response regulator (RR). They respond to environmental stimuli, and regulate gene expression by interacting with the transcription machinery. Thirteen complete TCSTSs have been identified in S. pneumoniae, along with a lone RR. This study focused on one of these systems, designated RR/HK06. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1255323 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2006
4

Characterisation of the capsular polysaccharide biosynthesis loci of streptococcus pneumoniae serogroup 19 /

Morona, Judy Kay. January 1998 (has links) (PDF)
Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1999? / Bibliography: leaves 250-227.
5

Acute respiratory infection in young children in Nairobi, Kenya : epidemiological, clinical and microbiological study

Kamiya, Yasuhiko January 2001 (has links)
No description available.
6

Vancomycin tolerance in streptococcus pneumoniae

Koo, Kun, 古軍 January 2002 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
7

Sorotipos, clones e susceptibilidade a antimicrobianos de Streptococcus Pneumoniae isolados em amostras de líquor no Estado do Paraná.

Marcon, Isabella 28 June 2011 (has links)
No description available.
8

Streptococcus pneumoniae : nasopharyngeal carriage and vaccine studies in the UK and Nepal

Hamaluba, Mainga January 2015 (has links)
Streptococcus pneumoniae is one of the leading causes of morbidity and mortality in children under 5. Low-income countries are disproportionally affected and data in these settings are lacking. Effective strategies to control disease include infant immunisation with pneumococcal protein-polysaccharide conjugate vaccines. However, ongoing surveillance of carriage and disease are important to understand the impact of vaccination within communities. This thesis evaluated nasopharyngeal (NP) carriage in 3 generations, following introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the UK. NP carriage was also compared between rural and urban Nepalese children and a novel method of delayed culture and transport was assessed. Finally, the immunogenicity of a 10-valent pneumococcal conjugate vaccine administered in a 2-dose priming schedule without a booster was compared to a 3-dose priming schedule with a booster in Nepalese infants. Key findings include carriage rates in UK children being similar to pre-PCV7 (7 valent pneumococcal conjugate vaccine) carriage rates at 47% with low carriage rates in seen in adults. PCV7 serotypes accounted for 1.5% of carriage isolates in children, 0% in parents and 15.4% in older adults. In Nepalese children carriage was higher in a rural (69.2%) compared to an urban setting (40.9%) and delayed culture and transport using silica desiccant packets (SDP) provided a reliable, albeit underestimated, estimate of carriage. Finally this author demonstrated that following primary immunisation and boosting, there was no difference in immune responses to serotypes 1, 5 and 14 with a 2 dose priming schedule compared to a 3-dose schedule. At 2-4 years of age a significantly higher proportion of vaccinees in the 2+1 group had ≥0·2µg/mL IgG for serotypes 1, 5, 6B and 18C compared to vaccinees in the 3+0 group.
9

Characterization of the role that bacterial surface polysaccharide poly N-acetyl glucosamine plays in nonvaccine serotypes of streptococcus pneumoniae colonization and pathogenicity

Jiang, Fanny 08 April 2016 (has links)
Poly N-acetyl glucosamine is a cell surface polysaccharide that has been characterized in Staphylococcus epidermidis and Staphylococcus aureus as involved in biofilm formation and implicated in virulence. Its role in bacterial colonization and pathogenicity is now being characterized in Streptococcus pneumoniae. The aim of this thesis was to produce PNAG-deficient S. pneumoniae mutants and to confirm differential levels of biofilm formation in PNAG-deficient mutants in comparison to their wild type strains. Using PCR, gel electrophoresis, and indirect immunofluorescence, successful transformations of PNAG-deficient mutants were confirmed. Biofilm assays provided preliminary data for further investigation of the role that PNAG plays in colonization in S. pneumoniae. A novel finding in PNAG genetic structure in S. pneumoniae was also discovered, providing a new avenue of research on PNAG.
10

Functional and evolutionary analyses of pneumococcal genome variation

Croucher, Nicholas Jason January 2012 (has links)
No description available.

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