Annotation Herta Gurskaitė The title of dissertation: Effects of new sulfonylcarbamide modulators of potassium channels (KACh and KATF) on the electromechanical activity of the heart. The aim of this study was to investigate the influence of new sulfonylcarbamide modulators of potassium channels (KACh and KATP) on the electromechanical activity parameters of guinea pig myocardium and the heart rhythm. The objectives of the scientific work were as follows: 1. To estimate the influence of carbachol, an activator of the muscarinic receptor-operated KACh channels, and pinacidil, an activator of KATP channels, and their blockers (atropine and glybenclamide) on the action potential (AP) duration and contraction force in guinea pig myocardium. 2. To investigate the effect of procainamide and its new sulfonylcarbamide derivatives on the AP duration and contraction force in guinea pig myocardium under the KACh and KATP channel activation. 3. To investigate the influence of 2-, and 4-aminopyridines and their new sulfonylcarbamide derivatives as well as 2-aminopyrimidine derivatives on the AP duration and contraction force in guinea pig myocardium under the KACh and KATP channel activation. 4. To determine the anticholinergic effect of the most potent new sulfonylcarbamide derivatives on the sinus rate in isolated guinea pig heart. 5. To determine, does the anticholinergic effect of the most effective sulfonylcarbamide compound was induced via blockade of M2-receptors and/or it... [to full text]