In Nigeria, seaport companies have lost significant revenue since 2000 because of supply chain disruptions. If not mitigated, supply chain disruptions at Nigerian seaports will significantly affect organizational output and profitability. The purpose of this research was to explore strategies some seaport business leaders use to mitigate supply chain disruptions in Lagos, Nigeria. Supply chain management theory was the conceptual framework for this single case study. Data were collected using semistructured interviews with 4 participants from a Nigerian seaport company tbat adopted successful strategies to mitigate supply chain disruptions and review of company documents for methodological triangulation. Using thematic analysis, the 5 primary themes were corruption, seaport congestion, bureaucratic bottleneck, equipment failures, and employee disputes. Customer satisfaction and business profitability were 2 primary strategies the business leaders in the study used to mitigate supply chain disruptions. By implementing the strategies identified in the study, business leaders in the Nigerian seaport sector may be able to bring about positive social change by increasing business profitability. The strategies could increase employment opportunities for people in seaport cities, thereby decreasing the poverty level and leading to a better standard of living for residents.