The common occurrence of coronary artery disease in man has led to considerable research concerning the problem of the ischemic myocardium. Many operative procedures have been developed, some of which have been used clinically. However, in contrast to the great advances in other aspects of cardiac surgery, such as congenital heart disease and chronic valvular disease, ischemic heart disease remains in an area in which progress has been slow. At the experimental level, one of the major problems is the assessment of revascularization procedures.(19) Even if some operative procedure can be developed in the experimental animal which is reasonably safe, one is still reluctant to offer this to the patient unless there is sufficient proof that it is likely to be beneficial to him.

Coronary sinus ligation was first performed by Gross, Blum and Silverman around 1935. Beck's work exploited the idea of blood redistribution and popularized this procedure. Vineberg, working with the principle that bringing new blood to the heart was more important, developed the Ivalon sponge operation. In this experimental study, an attempt was made to show if the combination of these two principles might add benefit to each individual revascularization procedure. Secondly, some details of the Ivalon sponge operation were evaluated.

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Thesis (PH. D.)--University of Chicago, 1920. / "Private edition, distributed by the University of Chicago Libraries, Chicago, Illinois." "Reprinted from American journal of physiology, vol. 53, no. 1, August, 1920." Bibliography: p. 135-136. Also available on the Internet.

Discussions with regard to circulatory alterations in shock and the end results of these changes have gone on for many years. As early- as 1944 vasoexcitor and vasodepressor substances in shock states were postulated and efforts were made to identify the substances responsible. These studies represented one of the first steps in the search to find a single substance as a common denominator in various forms of shock. Recent studies of polypeptides, their biological activity and affect on vasomotor tone have suggested their possible importance in shock states. The more recent studies by Moffat on Bradykinin release in pancreatitis, and by Thal on the release of vasoactive peptides in experimental bowel ischaemic shock models have been the two main studies that led to the quantitative measurement of the release of Bradykinin in experimental haemorrhagic shock.

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Akademisk avhandling--Uppsala. / Extra t.p., with thesis statement, inserted. Bibliography: p. 73-76.