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Management of Colorectal Liver Metastases in Older Patients: a Decision AnalysisYang, Simon Yie 31 December 2010 (has links)
BACKGROUND: The incidence of liver metastases from colorectal cancer (CLM) is on the rise. Older cancer patients are frequently subject to under-treatment. METHODS: A Markov decision model was built to examine the effect on life expectancy (LE) and quality-adjusted life expectancy (QALE) of four strategies – best supportive care (BSC), systemic chemotherapy (SC), radiofrequency ablation (RFA), and hepatic resection (HR). The model was designed to account for both age and comorbidities. RESULTS: In the base case analysis, BSC, SC, RFA, and HR yielded LEs of 11.9, 23.1, 34.8, and 37.0 months, respectively, and QALEs of 7.8, 13.2, 22.0, and 25.0 months, respectively. Model results were sensitive to several variables including age, comorbidity status, and length of model simulation. CONCLUSION: Hepatic resection may be the optimal treatment strategy for healthy older patients with CLM. Treatment decisions in older cancer patients should be individualized and account for patient age, comorbidities, and values.
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Management of Colorectal Liver Metastases in Older Patients: a Decision AnalysisYang, Simon Yie 31 December 2010 (has links)
BACKGROUND: The incidence of liver metastases from colorectal cancer (CLM) is on the rise. Older cancer patients are frequently subject to under-treatment. METHODS: A Markov decision model was built to examine the effect on life expectancy (LE) and quality-adjusted life expectancy (QALE) of four strategies – best supportive care (BSC), systemic chemotherapy (SC), radiofrequency ablation (RFA), and hepatic resection (HR). The model was designed to account for both age and comorbidities. RESULTS: In the base case analysis, BSC, SC, RFA, and HR yielded LEs of 11.9, 23.1, 34.8, and 37.0 months, respectively, and QALEs of 7.8, 13.2, 22.0, and 25.0 months, respectively. Model results were sensitive to several variables including age, comorbidity status, and length of model simulation. CONCLUSION: Hepatic resection may be the optimal treatment strategy for healthy older patients with CLM. Treatment decisions in older cancer patients should be individualized and account for patient age, comorbidities, and values.
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Pleural drainage after transthoracic oesophagectomy a five year experience with a vacuum system /Boey, Jir-ping. January 2001 (has links)
Thesis (M. Ed.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 59-66).
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An ethnogaphic [sic] interpretive approach to describing the clinical practice of registered nurses in the field of medical and surgical nursing practice /Oliver, Mary Swarna Philomena. January 2001 (has links) (PDF)
Thesis (Ph. D.)--University of Queensland, 2002. / Includes bibliographical references.
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Development of a hybrid robotic system for femur fracture reductionYe, Ruihua., 叶锐华. January 2011 (has links)
published_or_final_version / Mechanical Engineering / Doctoral / Doctor of Philosophy
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Pleural drainage after transthoracic oesophagectomy: a five year experience with a vacuum system梅值平, Boey, Jir-ping. January 2001 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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Mechanisms to improve the mechanical performance of surgical glovesWatkins, Michelle Hoyt 05 1900 (has links)
No description available.
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Bone biocompatibilty of polymer based materialsSasanaluckit, Piyamol Nuttanun January 1994 (has links)
No description available.
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Subacromial inflammation : clinical and experimental studies /Hoe-Hansen, Carsten. January 1900 (has links) (PDF)
Diss. (sammanfattning) Linköping : Univ., 2001. / Härtill 5 uppsatser.
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Postoperative mediastinitis : risk factors, wound contamination and diagnostic possibilities /Bitkover, Catarina Yael, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 4 uppsatser.
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