Bibliography : leaves 168-189. / xix, 197 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Examines the role of renin-angiotensin and sympathetic nervous systems in hypertension development in the spontaneously hypertensive rat. / Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1995?

Relatively few studies have examined the effects of nociception pe se on sympathetic nerve activity in awake healthy human subjects. Painful stimuli can produce differential responses from cutaneous and muscle postganglionic sympathetic neurones in the anaesthetised cat, and some animal and human studies suggest that nociceptive stimuli originating in different tissues may produce differential sympathetic effects- deep nociception causing vasodepressive and superficial nociception triggering an excitatory effect on cardiovascular state. It is important to understand how the sympathetic nervous system responds to nociception in healthy subjects in order to make more meaningful comparisons with the behaviour which occurs following damage to sympathetic pathways, e.g. nerve lesions (chronic regional pain syndromes) and spinal cord injury (autonomic dysreflexia (AD)). Additionally, it has been suggested that muscle spindles afferents may play a role in chronic pain, most notably the 'vicious cycle' of pain. While this has been investigated in animal studies, it has not been thoroughly investigated in healthy human subjects. Muscle spindle and sympathetic nerve activity from muscle and skin postganglionic neurones were directly recorded in healthy awake human subjects using microneurography; effector organ responses (blood pressure, heartrate, skin blood flow and sweat release) were recorded in both healthy and spinal cord injured subjects. Deep and superficial nociception was induced by intramuscular and subdermal injections of hypertonic saline given at unexpected times and in quasi-random order. Regardless of the origin of nociception (deep or superficial), general responses tended to be excitatory with increases seen in muscle and skin sympathetic nerve activity, heartrate, blood pressure and sweat release. A gender effect was noted regarding skin blood flow, with males largely showing decreases and females increases. No changes were noted in spindle firing rates and painful stimuli did not significantly increase effector organ responses in spinal cord injured subjects. Contrasting with previous studies, we did not see a differential sympathetic response or change in spindle firing rate to painful stimuli originating in different tissues. While it is believed that noxious stimuli trigger AD, we did not see exaggerated sympathetic responses in spinal cord injured subjects. More investigation is required regarding innocuous triggers of AD.

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 114-134).

Diss. (sammanfattning) Linköping : Linköpings universitet, 2008. / Härtill 4 uppsatser.

Thesis (Ph. D.)--University of Sydney, 2007. / Title from title screen (viewed 1 November 2007). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Physiology, Faculty of Medicine. Degree awarded 2007 ; thesis submitted 2006. Bibliography: leaves 239-284. Also issued in print.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 45-56). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 45-56). Also available on the Internet.

Thesis (Ph. D.)--University of Alberta, 2009. / Title from pdf file main screen (viewed on July 23, 2009). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Cell Biology, University of Alberta." Includes bibliographical references.

Akademisk avhandling--Karolinska Institutet, Stockholm. / Extra t.p., with thesis statement, inserted. Bibliography: p. 24-26.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1939. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaf [15]).