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Building Upon Supramolecular Synthons : Some Aspects of Crystal EngineeringMukherjee, Arijit January 2013 (has links) (PDF)
Crystal engineering offers a rational way of analyzing crystal structures and designing new structures with properties. The supramolecular synthon concept was introduced in 1995 and has shown versatility and utility in the design of molecular solids.
Chapter 1 gives a general introduction about the development of the concept of supramolecular synthons over the years which has seen a transition from synthesis to structures and dynamics. This thesis focuses on the later phase of the development of the concept of supramolecular synthons. Chapter 2 introduces the idea of structural landscape and describes a structural landscape of a conformationally flexible molecule, orcinol, and explores the synthon preferences of this particular molecule towards cocrystal formation. Chapter 3 explores a combinatorial matrix to show both global and local features of a structural landscape. Chapter 4 takes a component of this landscape namely 4,4'-bipyridine and 4-hydroxybenzoic acid and shows the occurrence of synthon polymorphism in cocrystals which originates from the interplay of geometrical and chemical factors. Chapter 5 introduces a four step method for the identification of multiple synthons by FTIR spectroscopy. Along with, it shows that the rarity of synthon polymorphism is not a case of overlooking of crystals in the process of selecting good looking crystals. Chapter 6 takes a series of dihalogenated phenols and indicates that the Br prefers type II. This chapter also explains elastic bending on the basis of halogen bonds. Chapter 7 attempts to explore the Cl/Br isostructurality in the light of type I and type II contacts and concludes that Cl/Br isostructurality arises from a geometrical model and therefore it is quite similar to Cl/Me isostructurality. Chapter 8 attempts to analyze the class of trichlorophenols and reveals structural modularity in this class of compounds. The modularity of 3,4,5-trichlorophenol is explored in crystal design in chapter 9 in terms of LSAM (Long Range Synthon Aufbau Module) A subsequent study in solution by NMR reveals the presence of LSAM in solution and establishes a hierarchy of the dissociation of its components.
The concept of supramolecular synthon has come a long way from being a tool in a crystal engineer’s toolbox to a structural unit responsible for crystallization and therefore offer multiple possibilities both in terms of structures and dynamics. This thesis attempts to explore some of these possibilities based mainly on the concepts of structural landscape and halogen bonds which are blended with the concept of supramolecular synthons.
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Structure-Function Control in Organic Co-Crystals/Salts Via Studies on Polymorphism, Phase Transitions and Stoichiometric VariantsKaur, Ramanpreet January 2015 (has links) (PDF)
The thesis entitled “Structure-function control in organic co-crystals/salts via studies on polymorphism, phase transitions and stoichiometric variants” consists of five chapters.
The main emphasis of the thesis is on two aspects, one to characterize co-crystal polymorphism in terms of propensity of intermolecular interactions to form co-crystals/salts or eutectics. The other aspect is to explore the feasibility of using such co-crystals/salts to exhibit properties like proton conduction, dielectric and ferroelectric behaviour. Gallic acid and its analogues possess functionalities to provide extensive hydrogen bonding capabilities and are chosen as the main component while the coformers are carefully selected such that they either accept or reject the hydrogen bonding offered. Such co-crystallization experiments therefore provide an opportunity to unravel the intricate details of the formation of crystalline polymorphs and/or eutectics at the molecular level. Further these co-crystal systems have been exploited to evaluate proton conductivity, dielectric and ferroelectric features since the focus is also on the design aspect of functional materials. In the context of identifying and utilizing Crystal Engineering tools, the discussions in the following chapters address not only the structural details but identify the required patterns and motifs to enable the design of multi-component co-crystals/salts and eutectics. In particular, the presence/absence of lattice water in gallic acid has been evaluated in terms of importing the required physical property to the system.
Chapter 1 discusses the structural features of tetramorphic anhydrous co-crystals (1:1; which are synthon polymorphs) generated from a methanolic solution of gallic acid monohydrate and acetamide, all of which convert to a stable form on complete drying. The pathway to the stable form (1:3 co-crystal) is explained based on the variability in the hydrogen bonding patterns followed by lattice energy calculations.
Chapter 2A studies the presence/absence and geometric disposition of hydroxyl functionality on hydroxybenzoic acids to drive the formation of co-crystal/eutectic in imide-carboxylic acid combinations. In Chapter 2B the crystal form diversity of gallic acid-succinimide co-crystals are evaluated with major implications towards the design and control of targeted multi-component crystal forms. The co-crystal obtained in this study shows a rare phenomenon of concomitant solvation besides concomitant polymorphism and thus making it difficult to obtain a phase-pure
crystal form in bulk quantity. This issue has been resolved and formation of desired target solid form is demonstrated. Thus, this study addresses the nemesis issues of co-crystallization with implications in comprehending the kinetics and thermodynamics of the phenomenon in the goal of making desired materials.
Chapter 3 focuses on the systematic co-crystallization of hydroxybenzoic acids with hexamine using liquid assisted grinding (LAG) which show facile solid state interconversion among different stoichiometric variants. The reversible interconversion brought about by varying both the acid and base components in tandem is shown to be a consequence of hydrogen bonded synthon modularity present in the crystal structures analyzed in this context.
In Chapter 4A, the rationale for the proton conduction in hydrated/anhydrous salt/co-crystal of gallic acid - isoniazid is provided in terms of the structural characteristics and the conduction pathway is identified to follow Grotthuss like mechanism which is supplemented by theoretical calculations. Chapter 4B describes an extensive examination of the hydrated salt of gallic acid-isoniazid which unravels the irreversible nature of the dielectric property upon dehydration and suggests that the “ferroelectric like” behaviour is indeed not authenticated. This chapter brings out the significance role of lattice water in controlling the resulting physical property (dielectric/ferroelectric in this case).
Chapter 5 describes the structural features of two hydrated quaternary salts of hydroxybenzoic acids-isoniazid-sulfuric acid and the phase transitions at both low and high temperatures are shown to be reversible. Single Crystal to Single Crystal (SCSC) in situ measurement corroborated by thermal and in situ Powder X-ray Diffraction studies proves the claim. Further, the properties exhibited by these materials are also governed by lattice water content.
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