No / Angiography is an important minimally invasive diagnostic procedure in endovascular interventions. Effective training for the procedure is expensive, time consuming and resource demanding. Realistic simulation has become a viable solution to addressing such challenges. However, much of previous work has been focused on software issues. In this paper, we present a novel hardware system-an interactive syringe device with haptics as an add-on hardware component to 3D VR angiography training simulator. Connected to a realistic 3D computer simulation environment, the hardware component provides injection haptic feedback effects for medical training. First, we present the design of corresponding novel electronic units consisting of many design modules. Second, we describe a curve fitting method to estimate injection dosage and injection speed of the contrast media based on voltage variation between the potentiometer to increase the realism of the simulated training. A stepper motor control method is developed to imitate the coronary pressure for force feedback of syringe. Experimental results show that the validity and feasibility of the new haptic syringe device for achieving good diffusion effects of contrast media in the simulation system. A user study experiment with medical doctors to assess the efficacy and realism of proposed simulator shows good outcomes. / National Natural Science Foundation of China (61402278), the Innovation Program of the Science and Technology Commission of Shanghai Municipality of China (16511101302), Research Program of Shanghai Engineering Research Center of Motion Picture Special Effects (16dz2251300)