Thesis (D. Min.)--Gordon-Conwell Theological Seminary, 2006. / Abstract and vita. Includes bibliographical references (leaves 111-115).

Thesis (Ph.D.)--Indiana University, Dept. of Counseling and Educational Psychology of the School of Education, 2007. / Adviser: Thomas L. Sexton. Includes bibliographical references (p. 131-148). Also available online.

Thesis (Th. M.)--Calvin Theological Seminary, 2006. / Abstract. Includes bibliographical references (leaves 104-110).

Thesis project (D. Min.)--Denver Seminary, 2005. / Includes bibliographical references (leaves 243-268).

This research used interviews and Interpretative Phenomenological Analysis (IPA) methodology to explore the experiences of care staff who attended systemic consultations within an Intellectual Disability (ID) service. A systematic literature review revealed limited research in the area of systemic approaches used with people with IDs and their networks. Research questions encompassed 'How do care staff experience systemic consultations that they have attended in ID services'?, 'What do care staff find helpful in systemic consultations'?, and, 'What do care staff find unhelpful in systemic consultations'?. Seven participants were interviewed, and interview data was transcribed and analysed using IPA. Five superordinate themes emerged; 'Not knowing what to expect; it was something different', 'Our relationships improved', 'An outside person shone a new light enabling us to think and work differently', 'Making sense of what we have achieved', and 'They made us feel validated'. The research findings highlighted important clinical implications. These included a need for the context to be 'warmed' and relational reflexivity (Bunham, 2005) to be applied in order to help care staff prepare for systemic consultations and feel supported. Future research directions are also discussed in order to develop the evidence-base for systemic approaches within ID services.

The purpose of this study was to compare western family therapy to the "imbizo" system that is used as a kind of family therapy in the black cultural environment. The "imbizo" system is different from western therapy in its composition. Relatives play a more prominent role than in western family therapy. The imbizo system provides unique support and aftercare to its clients. Unlike western therapy, it requires no payment of fees. The "imbizo" excludes children while western family therapy includes every family member as part of the system in the therapeutic process. Semi-structured interviews were conducted with three male respondents from the Nguni ethnic group and one male and two females from the Sotho ethnic group. / Psychology of Education / M. Ed. (Guidance and Counselling)

O carcinoma mucoepidermoide (CME) representa a neoplasia maligna de glândula salivar mais comum. Tumores com alto grau histológico e casos avançados, com metástase regional ou a distância, apresentam taxas de sobrevida extremamente baixas em decorrência da falta de terapias eficazes. A radioterapia é usualmente aplicada como terapia adjuvante ou primeira linha de tratamento de tumores inoperáveis, entretanto o perfil de resistência do CME à radioterapia permanece não elucidado. Outra abordagem em tumores avançados é a quimioterapia, usualmente a base de cisplatina, aplicada como tratamento meramente paliativo. Um dos principais pontos chave envolvidos na resistência tumoral às terapias convencionais é a manutenção de uma população celular com alto potencial tumorigênico, chamadas de células tronco tumorais (CTT). Estas células apresentam capacidade de evadir terapias convencionais e são responsáveis pelo aparecimento de metástases e recidivas. Evidências recentes sugerem que a utilização de terapias combinadas possuem maior potencial de reduzir a resistência tumoral. Desta forma, no primeiro estudo nosso objetivo foi identificar o perfil de resistência à radioterapia de linhagens celulares de CME, vias associadas com a radio-resistência adquirida e formas de sensibilizar farmacologicamente as células de CME, incluindo as CTT, à radiação ionizante. Os resultados demonstraram que as linhagens de CME apresentam diferentes perfis de resistência à radiação ionizante, sendo a linhagem mais resistente capaz de ativar intrinsicamente o NFκB frente a baixas doses de radiação. Além disso, a resistência das linhagens mais sensíveis foi estimulada quando a vida do NFκB foi excitada. A inibição farmacológica do NFκB com Emetine foi realizada com sucesso através da inibição do eixo IKK-β/IκBα/NFκB. A utilização de Emetine previamente a radiação ionizante foi capaz de aumentar a sensibilidade das células de CME assim como diminuir o percentual de CTT. No segundo estudo nosso objetivo foi identificar a resposta tumoral, incluindo das CTT, à terapia única ou combinada utilizando dois alvos terapêuticos distintos: NFκB (tratamento com Emetine) e acetilação de histonas (tratamento com SAHA). Os resultados mostraram que uma dose de Emetine é capaz de inibir a proliferação celular em todas as linhagens de CME analisadas, enquanto que o SAHA apresentou este efeito em apenas 50% das linhagens. Por outro lado, o SAHA foi mais eficaz em reduzir a população de CTT que o Emetine. A terapia combinada foi mais eficaz do que as terapias individuais em relação a proliferação celular e a depleção de CTT. Através da analise dos resultados dos dois estudos, podemos concluir que a resistência tumoral do CME é superada com maior êxito quando mais de uma forma de tratamento é empregada. A associação de Emetine com a irradiação ou de SAHA com Emetine se mostrou eficaz no controle do tumor através da erradicação da população de CTT. / Mucoepidermoid carcinoma (MEC) represents the most common salivary gland cancer. High-grade tumors and advanced cases, presenting regional or distant metastasis, exhibit extremely low survival rates due to a lack of effective therapies. Radiotherapy is frequently applied as adjuvant therapy or as first-line treatment in inoperable cases. Nevertheless, the resistance profile of MEC to radiotherapy remains unclear. Chemotherapy, most commonly cisplatin, used for advanced cases is considered merely palliative. A key point involved in tumor resistance to conventional therapies is the maintenance of a cell population with high tumorigenic potential, called cancer stem cells (CSC). These cells have the ability to evade conventional therapies and are responsible for metastases and recurrences. Recent evidences support that combined therapies are more effective in reducing tumor resistance. Therefore, in the first study our objective was to identify the resistance profile of MEC cell lines to ionizing radiation, pathways associated with acquired resistance and ways to sensitize pharmacologically MEC cells, including CSC, to ionizing radiation. The results demonstrated that MEC cell lines present different resistance profile to ionizing radiation and the most resistant cell line is capable to activate intrinsically NFκB after low doses of irradiation. Moreover, resistance of sensitive cell lines can be triggered by NFκB activation. Pharmacological inhibition of NFκB with Emetine was achieved through IKK-β/IκBα/NFκB axis inhibition. The use of Emetine prior to irradiation was efficient in increasing cell sensibility as well as decrease the percentage of CSC. In the second study, our aim was to identify the tumor response, including of CSC, to single or combined therapy using two distinc therapeutic targets: NFκB (treated with Emetine) and histone acetylation (treated with SAHA). The results demonstrated that a single dose of Emetine was capable to inhibit cell proliferation in all MEC cell lines, while SAHA achieved this result in only 50% of cell lines analyzed. On the other side, SAHA was more efficient than Emetine in disrupting CSC population. The combined therapy was more effective than both single agent therapies regarding cell proliferation and CSC depletion. By analysing both studies results, we can conclude that the tumor resistance of MEC is overcome with greater success when more than one form of treatment is employed. The association of Emetine with irradiation or SAHA with Emetine is effective in tumor control by eradicating the CSC population.

The work is focused on forms of influence of systemic therapy and psychotherapy on human´s psyche. Theoretical party classifies individuals with mental disease, concerns with psychotherapy, and problems of systemic therapy, psyche in general and psyche of individuals with mental disease and therapy used on people with mental disease. Practical part investigates the influence of systemic therapy and psychotherapy on psyche of people with mental disease and instruments used for systemic therapy of individuals with mental disease. Results of this research show positive influence of systemic therapy and psychotherapy on individual with mental disease.

O carcinoma mucoepidermoide (CME) representa a neoplasia maligna de glândula salivar mais comum. Tumores com alto grau histológico e casos avançados, com metástase regional ou a distância, apresentam taxas de sobrevida extremamente baixas em decorrência da falta de terapias eficazes. A radioterapia é usualmente aplicada como terapia adjuvante ou primeira linha de tratamento de tumores inoperáveis, entretanto o perfil de resistência do CME à radioterapia permanece não elucidado. Outra abordagem em tumores avançados é a quimioterapia, usualmente a base de cisplatina, aplicada como tratamento meramente paliativo. Um dos principais pontos chave envolvidos na resistência tumoral às terapias convencionais é a manutenção de uma população celular com alto potencial tumorigênico, chamadas de células tronco tumorais (CTT). Estas células apresentam capacidade de evadir terapias convencionais e são responsáveis pelo aparecimento de metástases e recidivas. Evidências recentes sugerem que a utilização de terapias combinadas possuem maior potencial de reduzir a resistência tumoral. Desta forma, no primeiro estudo nosso objetivo foi identificar o perfil de resistência à radioterapia de linhagens celulares de CME, vias associadas com a radio-resistência adquirida e formas de sensibilizar farmacologicamente as células de CME, incluindo as CTT, à radiação ionizante. Os resultados demonstraram que as linhagens de CME apresentam diferentes perfis de resistência à radiação ionizante, sendo a linhagem mais resistente capaz de ativar intrinsicamente o NFκB frente a baixas doses de radiação. Além disso, a resistência das linhagens mais sensíveis foi estimulada quando a vida do NFκB foi excitada. A inibição farmacológica do NFκB com Emetine foi realizada com sucesso através da inibição do eixo IKK-β/IκBα/NFκB. A utilização de Emetine previamente a radiação ionizante foi capaz de aumentar a sensibilidade das células de CME assim como diminuir o percentual de CTT. No segundo estudo nosso objetivo foi identificar a resposta tumoral, incluindo das CTT, à terapia única ou combinada utilizando dois alvos terapêuticos distintos: NFκB (tratamento com Emetine) e acetilação de histonas (tratamento com SAHA). Os resultados mostraram que uma dose de Emetine é capaz de inibir a proliferação celular em todas as linhagens de CME analisadas, enquanto que o SAHA apresentou este efeito em apenas 50% das linhagens. Por outro lado, o SAHA foi mais eficaz em reduzir a população de CTT que o Emetine. A terapia combinada foi mais eficaz do que as terapias individuais em relação a proliferação celular e a depleção de CTT. Através da analise dos resultados dos dois estudos, podemos concluir que a resistência tumoral do CME é superada com maior êxito quando mais de uma forma de tratamento é empregada. A associação de Emetine com a irradiação ou de SAHA com Emetine se mostrou eficaz no controle do tumor através da erradicação da população de CTT. / Mucoepidermoid carcinoma (MEC) represents the most common salivary gland cancer. High-grade tumors and advanced cases, presenting regional or distant metastasis, exhibit extremely low survival rates due to a lack of effective therapies. Radiotherapy is frequently applied as adjuvant therapy or as first-line treatment in inoperable cases. Nevertheless, the resistance profile of MEC to radiotherapy remains unclear. Chemotherapy, most commonly cisplatin, used for advanced cases is considered merely palliative. A key point involved in tumor resistance to conventional therapies is the maintenance of a cell population with high tumorigenic potential, called cancer stem cells (CSC). These cells have the ability to evade conventional therapies and are responsible for metastases and recurrences. Recent evidences support that combined therapies are more effective in reducing tumor resistance. Therefore, in the first study our objective was to identify the resistance profile of MEC cell lines to ionizing radiation, pathways associated with acquired resistance and ways to sensitize pharmacologically MEC cells, including CSC, to ionizing radiation. The results demonstrated that MEC cell lines present different resistance profile to ionizing radiation and the most resistant cell line is capable to activate intrinsically NFκB after low doses of irradiation. Moreover, resistance of sensitive cell lines can be triggered by NFκB activation. Pharmacological inhibition of NFκB with Emetine was achieved through IKK-β/IκBα/NFκB axis inhibition. The use of Emetine prior to irradiation was efficient in increasing cell sensibility as well as decrease the percentage of CSC. In the second study, our aim was to identify the tumor response, including of CSC, to single or combined therapy using two distinc therapeutic targets: NFκB (treated with Emetine) and histone acetylation (treated with SAHA). The results demonstrated that a single dose of Emetine was capable to inhibit cell proliferation in all MEC cell lines, while SAHA achieved this result in only 50% of cell lines analyzed. On the other side, SAHA was more efficient than Emetine in disrupting CSC population. The combined therapy was more effective than both single agent therapies regarding cell proliferation and CSC depletion. By analysing both studies results, we can conclude that the tumor resistance of MEC is overcome with greater success when more than one form of treatment is employed. The association of Emetine with irradiation or SAHA with Emetine is effective in tumor control by eradicating the CSC population.

In der systemischen Therapie besteht weitestgehend eine kritische Haltung gegenüber Diagnosen. Aufgrund der Ende 2018 erfolgten sozialrechtlichen Anerkennung der systemischen Therapie als Kassenleistung und der damit verbundenen Verpflichtung zur Diagnosevergabe werden Diagnosen derzeit besonders kontrovers diskutiert. Vor diesem Hintergrund werden auf verschiedenen Systemebenen die Bedeutungen untersucht, die Diagnosen in der systemischen Therapie zukommen können. Dabei werden u.a. die Perspektive des Klienten, des Therapeuten und der Gesellschaft betrachtet, immer verbunden mit der Frage, welche Bedeutungen Diagnosen für die jeweiligen Akteure erhalten und entfalten können. Die empirische Basis der Untersuchung bilden Experteninterviews mit systemischen Therapeutinnen, die mithilfe der qualitativen Inhaltsanalyse ausgewertet werden. Ziel ist, anhand der getroffenen Aussagen verschiedene Bedeutungszuschreibungen von Diagnosen zu identifizieren. In den Ergebnissen zeigen sich vielfältige beobachtete Bedeutungszuschreibungen von Diagnosen. Zudem wird auf der Systemebene „Therapeut“ deutlich, dass die interviewten Therapeutinnen die Verpflichtung zur Diagnosevergabe mitunter als belastend empfinden. Die Innensicht systemischer Therapeutinnen im Umgang mit Diagnosen, aber auch die identifizierten Bedeutungszuschreibungen auf den anderen Systemebenen zeigen ein über die systemische Therapie hinausgehendes hochrelevantes Themenfeld auf, das zukünftig in der Psychotherapieforschung weiter untersucht werden sollte.