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T cells from immunological memory to autoimmune diseaseBell, James Jeremiah, January 2006 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2006. / Title from title screen of research.pdf file (viewed December 22, 2006). The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2006" Includes bibliographical references.
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The delivery of exogenous peptides into the class I processing and presentation pathway using the B subunit of Escherichia coli heat labile enterotoxinHearn, Arron R. January 2003 (has links)
No description available.
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Human leucocyte antigen matching and the development of helper and cytotoxic activity by alloreactive lymphocytesYoung, Neil T. January 1997 (has links)
No description available.
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Analysis of gamma-delta T cells in black South African patients with active tuberculosisSedick, Qanita January 2014 (has links)
A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree, Master of Medicine in Haematopathology. Johannesburg, 2014 / Mycobacterium Tuberculosis is the leading cause of morbidity and mortality due to infectious diseases worldwide. South Africa has ~20% of the world’s HIV associated Tuberculosis and has the second largest reported numbers of multidrug resistant (MDR) Tuberculosis in the world.
Given the complexity of the mycobacterium and its ability to evade the immune system, there is a need for dissecting the immunological response to Tuberculosis including innate like lymphocytes such as gamma-delta T cells. Gamma-delta T cells are of particular relevance as they react to phospho-proteins of mycobacteria. Gamma-delta T cells can be divided into two subsets. Gamma-delta T cells using the Vdelta2 (VD2) segment as the variable segment in their T cell receptor and gamma-delta T cells using an alternative variable segment (non VD2 T cells).
We aimed to enumerate both subsets of gamma-delta T cells in the immunological response to Tuberculosis. We collected samples from three patient populations at the Charlotte Maxeke Johannesburg Academic Hospital for comparison: HIV positive patients with no evidence of Tuberculosis disease, HIV positive patients with active pulmonary Tuberculosis and a healthy control group. We used a nine colour flow cytometric panel to enumerate the frequency of gamma-delta T cells in these participant groups.
We found that the VD2 T cell subset was reduced in the HIV positive group and the dual HIV positive TB positive group compared with healthy controls, which mirrored the loss of CD4 T cells in these patients. Conversely, the non VD2 subset of gamma-delta T cells showed a statistically significant increased frequency in HIV positive patients and dual HIV positive TB positive patients compared to healthy controls. The frequency of gamma-delta T cells, expressed as a percentage of total T cells, was significantly increased in HIV positive patients and not non- significantly increased in the HIV positive TB positive groups compared to healthy controls.
This skewing of the gamma-delta T cell repertoire in HIV positive patients and HIV positive patients with active Tuberculosis may have specific immune implications. The mechanism of the loss of VD2 T cells in HIV and HIV associated Tuberculosis has not been elucidated. The loss of VD2 gamma-delta T cells in HIV and HIV associated Tuberculosis may underlie susceptibility to Tuberculosis disease.
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T-cell interactions in the foreign body response to biomaterialsRodriguez, Analiz. January 2007 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2007. / [School of Medicine] Department of Pathology. Includes bibliographical references.
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Th2 specific immunity and function of peripheral T-cells is regulated by the p56Lck SH3 domainMcCoy, Margaret Ellen. January 1900 (has links)
Thesis (Ph.D)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Microbiology & Immunology. Title from title-page of electronic thesis. Bibliography: leaves 191-222.
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The effect of enforced Notch signaling on TCR beta, positive, and negative selection of developing T cells /Huang, Eugene Y. January 2003 (has links)
Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 92-112).
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Thrombospondin 1, an autocrine regulator in T cell adhesion and migration /Li, ShuShun, January 2005 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2005. / Härtill 4 uppsatser.
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T lymphocytes in Wegener's granulomatosis /Giscombe Stephen, Ricardo Antonio, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.
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CD4+ T cell help for CD8+ T cell responses /Tyznik, Aaron Jacob. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 113-121).
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