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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
111

Presentation to and priming of human cd8⁺ T lymphocytes /

Zarling, Angela Lee, January 1999 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 1999. / "May 1999." Typescript. Vita. Includes bibliographical references (leaves 199-250). Also available on the Internet.
112

Constitutive expression of costimulatory ligands in tumor antigen-specific human T lymphocytes : a study investigating the therapeutic potential of auto- and transcostimulation in cancer immunotherapy /

Stephan, Matthias. January 2008 (has links)
Thesis (Ph. D.)--Cornell University, May, 2008. / Vita. Includes bibliographical references (leaves 101-121).
113

Alterations in T cell function and activation during exposure to the herbicide 3,4-dichloropropionanilide (DCPA) and its metabolites

Lewis, Tricia L. January 2010 (has links)
Thesis (Ph. D.)--West Virginia University, 2010. / Title from document title page. Document formatted into pages; contains x, 170 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
114

Spreading capacity and cytochalasin-induced capping as probes for plasma membrane/cytoskeletal function in human T-lymphocytes

Otteskog, Per. January 1982 (has links)
Thesis (doctoral)--Karolinska Institutet, Stockholm, 1982. / Extra t.p. with thesis statement inserted. Includes bibliographical references.
115

CD25⁺ CTLA-4⁺ T Cell-dependent induction of anergic CD25⁻ T cells limits the immune response to H. Pylori infection resulting in mild gastritis and persistent colonization /

Anderson, Kathleen. January 2006 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2006. / [School of Medicine] Department of Pathology. Includes bibliographical references. Available online via OhioLINK's ETD Center.
116

The modulation of CD4⁺ T lymphocyte activity by adenosine A₂[A] receptor activation /

Lappas, Courtney Marcia. January 2006 (has links)
Thesis (Ph. D.)--University of Virginia, 2006. / Includes bibliographical references. Also available online through Digital Dissertations.
117

Modulation of naive CD4+ Tcell activation and dendritic cell function in the lungs during pulmonary mycobacterial infection

Anis, Mursalin M. January 2007 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2007. / [School of Medicine] Department of Pathology. Includes bibliographical references. Available online via OhioLINK's ETD Center.
118

The role of chronically stimulated and senscent T cells in autoimmunity

Ratts, Robert Bruce January 2006 (has links)
Dissertation (Ph.D.) -- The University of Texas Southwestern Medical Center at Dallas, 2006. / Embargoed. Vita. Bibliography
119

A novel T cell activating factor

Williams, Laura Dawn January 1987 (has links)
The maturation of cytotoxic T lymphocyte (CTL) effectors from CTL precursors (CTLp) requires specific signals mediated through cellular interactions and soluble factors. The most studied factor is T cell growth factor (TCGF) which is also termed interleukin-2 (IL-2). This lymphokine is produced by T helper cells (TH) and induces activated CTLp to proliferate and differentiate. However, in the absence of mitogen or antigen stimulation, IL-2 alone cannot induce CTL (except in the case of very high cell density). A factor is described that is found in the supernatant of 4-β-phorbol-12-myristate-13-acetate (PMA)-induced EL4 cells that can polyclonally activate CTL in the presence of IL-2. This factor elutes at 27 kilodaltons (KDa) on a G-100 column, and its target cell includes T cells of the Thyl⁺ Lyt2⁺ L3T4⁻ phenotype. The factor increases the frequency of IL-2 receptor expressing cells within a population, thereby increasing the response to IL-2. It is suggested that this factor acts through an alternative pathway of CTL activation which is independent of specific stimulation by antigen. / Medicine, Faculty of / Medical Genetics, Department of / Graduate
120

Antigen-specific helper T cells in the responses of DBA/2 mice to a syngeneic tumour, P815

Hancock, Elizabeth Jane January 1983 (has links)
When injected with live P815 tumour cells, DBA/2 mice developed cytotoxic cells reactive to the tumour. In addition, T helper cells from tumour-bearing mice enhanced the iri vitro generation of cytotoxic cells from normal DBA/2 spleen cells. The helper cells had the following properties (1) expression of the Thy-1.2 antigen; (2) resistance to y-radiation; (3) specific enhancement of the cytotoxic response to P815; (4) detectability in P815-bearing mice at the peak of cytotoxic cell activity; (5) activity in the early phase of cytotoxic cell activation. In parallel to the development of helper cell activity, suppressor cells were generated which suppressed the cytotoxic response to P815. These suppressor cells were removed by pre-treating mice with low doses of cyclophosphamide. High doses of cyclophosphamide reduced the cytotoxic response to both P815 and C57B1/6 alloantigens. Cyclophosphamide treatment reduced the frequency of cytotoxic precursor cells directed against P815, and an antigen-reactive helper cell involved in interleukin 2 production. Both interleukin 2 and thymocytes from P815-primed mice, restored the cytotoxic response against P815, to normal levels. Twenty six percent of animals primed with tumour cells cleared a challenge dose of P815 faster than unprimed control mice. Of these, 88% survived longer than the control animals. Eighteen percent of the recipients of cells from tumour-primed mice, cleared a challenge dose of P815 faster than mice injected with normal cells. Of these 53% survived significantly longer than control groups given either normal cells or no cells at all. Cells from mice primed to PPD showed significantly enhanced proliferative responses to soluble and P815-bound PPD, when compared with unprimed animals. However, cells from only a few PPD-primed mice showed enhanced cytotoxicity against P815 tumour cells, and PPD-primed cells either did not alter, or suppressed, the cytotoxic response of normal DBA/2 spleen cells, when stimulated with PPD-coated P815. / Science, Faculty of / Microbiology and Immunology, Department of / Graduate

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