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Role of splenic B cells and gamma delta T cells in the induction of peripheral tolerance elicited through the anterior chamber of the eyeAshour, Hossam Mohamed January 2006 (has links)
Dissertation (Ph.D.) -- University of Texas Southwestern Medical Center at Dallas, 2006. / Vita. Bibliography: pp. 124-137
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The Role of myeloid-derived suppressor cells in the immunotherapy of breast carcinomas /Morales, Johanna Keeler, January 2009 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Microbiology and Immunology. Bibliography: leaves 267 - 296. Also available online via the Internet.
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The roles of the transcription factor Foxp3 in the development and maintenance of the regulatory T cell lineage /Williams, Luke M. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 88-100).
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CD25⁺ CTLA-4⁺ T Cell-dependent induction of anergic CD25⁻ T cells limits the immune response to H. Pylori infection resulting in mild gastritis and persistent colonization /Anderson, Kathleen. January 2006 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2006. / [School of Medicine] Department of Pathology. Includes bibliographical references. Available online via OhioLINK's ETD Center.
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Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /Cabbage, Sarah E. January 2006 (has links)
Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 92-107).
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The role of CD4⁺ Foxp3⁺ naturally-occurring regulatory T cells in the host immune response to Plasmodium chabaudi AS /St-Pierre, Jessica. January 2007 (has links)
Naturally-occurring CD4+Foxp3+ regulatory T cells (nTreg) play a central role in maintaining immune self-tolerance as well as modulating immunity towards pathogens. Pathogens may establish chronic infections in immunocompetent hosts by engaging nT reg in order to promote immunosuppression. The goal of the research described here is to test the hypothesis that nTreg modulate protective immunity to malaria, and consequentially affect susceptibility to the parasite. To investigate this question, the functional dynamics of CD4+Foxp3 + nTreg cells were evaluated in mice infected with blood-stage Plasmodium chabaudi AS. Adoptive transfer of nTreg to infected wild-type C57BL/6 (B6) mice or infection of transgenic B6 mice over-expressing Foxp3 resulted in increased parasitemia and reduced survival compared to control mice. Moreover, while resistant B6 mice exhibited decreased splenic nT reg frequencies at day 7 post infection, susceptible A/J mice maintained high numbers of nTreg at this time. Investigation of the effects of nTreg regulation on immune cell function in P. chabaudi AS-infected mice revealed that increased nTreg frequencies led to decreased malaria-specific lymphoproliferation and increased systemic levels of IL-10. Unlike B6 mice, increased splenic nTreg frequencies in infected A/J mice correlated with decreased effector T cell proliferation and IFN-gamma secretion, decreased B cell and NK cell proliferation as well as deficient IFN-gamma secretion by NK cells. Finally, nTreg proliferated within infected sites in both B6 and A/J mice, albeit to a greater extent in susceptible A/J mice. Altogether, these results demonstrate that nTreg suppressed anti-malarial immunity, and in turn promoted parasite growth and persistence.
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The importance of CTLA-4 and HLA class II for type 1 diabetes immunology /Jonson, Carl-Oscar, January 2007 (has links) (PDF)
Diss. (sammanfattning) Linköping : Linköpings universitet, 2007. / Härtill 4 uppsatser.
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TGF-[beta]-induced regulatory T cells in type I diabetes : function and antigen dependence /Tonkin, Daniel R. January 2007 (has links)
Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 182-202). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /Soper, David Michael. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 88-106).
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Impaired T cell receptor signaling in regulatory T cells /Carson, Bryan David. January 2006 (has links)
Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 91-98).
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