In this thesis we describe an approach to automatically invent/explore new mathematical theories, with the goal of producing results comparable to those produced by humans, as represented, for example, in the libraries of the Isabelle proof assistant. Our approach is based on ‘schemes’, which are formulae in higher-order logic. We show that it is possible to automate the instantiation process of schemes to generate conjectures and definitions. We also show how the new definitions and the lemmata discovered during the exploration of a theory can be used, not only to help with the proof obligations during the exploration, but also to reduce redundancies inherent in most theory-formation systems. We exploit associative-commutative (AC) operators using ordered rewriting to avoid AC variations of the same instantiation. We implemented our ideas in an automated tool, called IsaScheme, which employs Knuth-Bendix completion and recent automatic inductive proof tools. We have evaluated our system in a theory of natural numbers and a theory of lists.

Gene expression is the conduit by which genetic information is connected into cellular phenotypes. Recently, it was shown that gene expression in mammalian cells is governed, at least in part, by the expression of short double stranded RNA (dsRNA). This mode of gene regulation is influenced by a large group of dsRNA binding proteins that could either stabilize or trigger the degradation of dsRNA. Indeed, double stranded RNA (dsRNA) specific ribonucleases (RNases) play an important role in regulating gene expression. In most eukaryotes, members of the dsRNA specific RNase III family trigger RNA degradation and initiate cellular immune response. Disruption of human . RNase III (Dicer) deregulates fetal gene expression and promotes the development of cancer. However, very little is known about the housekeeping function of eukaryotic RNase III and the mechanism by which they distinguish between exogenous and endogenous cellular RNA species. This thesis elucidates how dsRNAs are selected for cleavage and demonstrates their contribution to RNA metabolism in yeast as model eukaryote. Initially, the reactivity determinants of yeast RNase III (Rnt1p) were identified in vitro and used to study the global impact of Rnt1p on the processing of non-coding RNA. The results indicate that Rnt1p is required for the processing of all small nucleolar RNAs (snoRNAs) involved in rRNA methylation and identify a new role of Rnt1p in the processing of intronic snoRNAs. It was shown that Rnt1p cleavage helps to coordinate the expression of some ribosomal protein genes hosting intronic snoRNAs. Direct snoRNA processing from the pre-mRNA blocks the expression of the host gene, while delayed snoRNA processing from the excised intron allows the expression of both genes. In this way, the cell can carefully calibrate the amount of snoRNA and ribosomal proteins required for ribosome biogenesis. In addition, a global analysis of snoRNA processing identified new forms of Rnt1p cleavage signals that do not exhibit a conserved sequence motif but instead use a new RNA fold to recruit the enzyme to the cleavage site. This finding led to the conclusion that Rnt1p may use a wide combination of structural motifs to identify its substrates and thus increases the theoretical number of potential degradation targets in vivo . To evaluate this possibility, a new search for snoRNA independent Rnt1p cleavage targets was performed. Interestingly, many Rnt1p cleavage signals were identified in intergenic regions devoid of known RNA transcripts. In vivo , it was shown that Rnt1p induce the termination of non-polyadenylated transcripts and functions as a surveillance mechanism for transcription read-through. This finding directly links Rnt1p to the transcription machinery and provides a new mechanism for polyadenylation independent transcription termination. Together the work described in this thesis presents an example of how eukaryotic RNase III may identify its substrates and present a case study where transcription, RNA processing and stability are linked.

International Telemetering Conference Proceedings / October 30-November 02, 1995 / Riviera Hotel, Las Vegas, Nevada / Flight Termination is a control action that takes place when missiles or targets violate estabished safety criteria. The flight termination receiver, part of a ground to air control loop, is characterised by high system integrity and dedication to recovering and decoding the command signals. The paper describes the factors that have influenced the design and build of a robust Pulse Code Modulation Flight Termination Receiver for use on UK Trial Ranges. This work has been carried out with the support of UK MoD(PE), A ARM 51, on contract number A ARM 13b/224.

Given the high rates of premature termination in training clinics, research aimed at understanding client attrition is urgently needed. Recent investigations in this area have implicated expectations of psychotherapy as a strong predictor of premature termination; however, this phenomenon has only been studied from the perspective of client expectations to date. There is reason to believe clinician expectations for the duration and effectiveness of psychotherapy may further impact the likelihood of their clients terminating prematurely. This study sought to address this gap in the literature by examining the association of clinicians' expectations to clients' psychotherapy outcomes and termination status in a training clinic setting. Clinicians were found to hold significantly higher expectations for client improvement than would be expected, and these high expectations were found to be positively correlated with clinically significant change in clients. Implications for improving client retention and treatment outcome in training clinics are discussed.

Housing is one of the basic needs of everyone. If this need is not satisfied, one does not feel safe. In fact, one suffers in other respects, does not have privacy and is not able to engage in other activities. There are various ways how to realize the need of housing. Nevertheless, the biggest limiting factor is the financial situation of the person. Therefore, the vast majority of the population lives in a leased flat these days. The lessee is in the position of the weaker party regarding the contract. Therefore, the law provides a special legal protection for the lessee. I decided to write a diploma thesis that would concern the housing law. It happened after passing optional subject called Housing law and I have gained valuable knowledge about legal issue of lease housing. Frankly, I was impressed by its dynamics and frequency. I chose a comparative topic thanks to my study abroad in Wrocław within the Erasmus programme. That programme provided me an access to Polish literature. Moreover, I had a great opportunity to consult the Polish law with lawyers teaching me at the University of Wrocław. The main aim of my diploma thesis is to analyse the ways of the legal regulation of termination of flat lease in the Czech Republic and Poland. This corresponds to the structure of the thesis. The first...

Exclusion And Withdrawal of Members And Cancellation of Their Membership In a Limited Liability Company Abstract This thesis aims to analyze current legislation of exclusion and withdrawal of members and cancellation of their membership in a limited liability company. Although comparing the current legislation with the previous one is not the purpose of the thesis, such comparison is provided in several places. The purpose is to show the same or, conversely, different features of both, particularly in relation to the applicability of existing case law and doctrinal interpretation. The work consists of three main chapters that form a coherent wholes. The first chapter is devoted to the withdrawal of a member of a limited liability company and is further divided into several sub-chapters. It deals with the legal aspects of the withdrawal of a member under the Czech legislativ. It describes in detail the various reasons of the withdrawal and also offers some suggestions de lege ferenda. The second chapter focuses on the exclusion of a shareholder of a limited liability company by the general meeting. It brings an analysis of legislation, describes the procedure of exclusion and analyzes the available case law. The third chapter, entitled "Termination of participation of a member of a limited liability company...

The diploma thesis is focused on the apartment lease termination. The goal of the thesis is to analyse legislation of the ways of apartment lease termination which are the most important in practice. Specifically it includes an agreement, an expiry of the period, a notice and a death of a lessee. Another goal of the thesis is to identify and aim at shortcomings of the current legislation and also to propose their suitable solutions. The thesis consists of introduction, three parts and conclusion. It draws information from legal regulations, legal literature, case law and other. The first part of the thesis deals with general characteristics of apartment lease and its termination. The legislation, basic features of apartment lease and its termination are described there and also the classification of the ways of apartment lease termination is done there. The second part of the thesis describes the ways of apartment lease termination except notice. At first the attention is concentrated on an agreement about apartment lease termination, mainly its form and consequences followed from a breach of the form. Then the thesis is focused on apartment lease termination by expiry of the period and also on renewal of lease which relates to it. Subsequently problems of a death of the lessee and the passage of...

Legal acts aimed at the termination of employment Abstract The aim of this thesis is to provide a comprehensive picture of the current and future new regulations on legal acts leading to the termination of employment. The thesis consists of seven chapters, each of them dealing with different issues. The first chapter is devoted to legal acts in general, to the employment relationship and its termination. It specifies what a legal act is and defines its requisites. The definition of the employment relationship and its termination are dealt with in its two subchapters. The second chapter concentrates on one of the legal acts leading to the termination of employment - the mutual termination agreement. This chapter consists of two subchapters, the first one specifying the requisites of the mutual termination agreement, the second one containing a concluding interpretation of this kind of agreement. The third chapter is devoted to the notice of termination of employment, the unilateral legal act resulting in the termination of the employment relationship. This chapter contains five subchapters. The first one deals with the notice period, mainly with its length, its course and its regulation in the conceptual amendment to the Czech Labour Code. The second subchapter concentrates on the notice of termination of...

Community property of spouses - termination and settlement The topic of my thesis is called Community property between spouses, its termination and settlement. I have chosen this particular topic because I am interested in this area and in civil law in general and also I find it very important. Community property of spouses is a specific type of property partnership, which can exist only between spouses. The community property of spouses origins and terminates together with the marriage. Upon the termination of marriage, community property of spouses also terminates and needs to be settled. The thesis is composed of six chapters which further include under-chapters and sections. At the beginning there is an introduction into the history and development of the legal regulations of community property of spouses. Attention is given to the great amendment of the Civil Code carried into affect by Act No. 91/1998 Coll., which has brought many changes into the legal regulations of community property of spouses. Chapter two defines the basic terms connected with the issue of the community property of spouses, namely concept, establishment, subject of community property of spouses, property assets and debits of the spouses, exclusive property of each of them and also community property in connection with...

The legal reasons of termination of residental lease - current and future legislation The thesis is composed of five separate chapters and a comparison table as an annex. The paper analyzes the different reasons for the termination of a lease of flat according to currently active legislation and the legislation that comes into force on January 1, 2014. The author chose this topic because the issue of housing and residential lease affects all of us and it is thus important to recognize the exact content of individual reasons for termination. Given that a radical change awaits us in this field, the author decided to compare and evaluate the future legislation. The first chapter outlines a historical development of the reasons for termination in our modern democratic history. Primarily, it focuses on the changes that have been brought upon the termination reasons by the Act No. 107/2006 Coll. and 132/2011 Coll. To maintain a better consistency of the paper, the second chapter examines the basic terminology and assess where and how they are regulated today and how they will be in a few months time. In particular, the author provides the definitions of a flat, lease contract, parties to the lease contract, and describes various options of termination of the lease of flat. Similarly, the author deals...