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Functional assessment and development of treatment strategies for brain tumors: promoting neurorestoration and reducing harm to bystander cells and neuroplasticity / Promoting neurorestoration and reducing harm to bystander cells and neuroplasticityYang, Hongyan, 1979- 29 August 2008 (has links)
Current treatment options for malignant brain tumors not only frequently fail to cure the disease due to local recurrence, but also may severely compromise quality of remaining life even when tumor mass is reduced in large part because they interfere with mechanisms of neuroplasticity and function of bystander tissue. The aims of this dissertation are to: (a) assess neurological impairments associated with rapid focal cortical tissue displacement; (b) evaluate the specific impact of conventional and novel treatments on neurorestoration while controlling tissue compression without the confound of related events linked to tumor physiology; (c) identify the behavioral change pattern during brain tumor progression and investigate the stealth nature of brain tumors; (d) demonstrate how anti-cancer treatments affect brain function especially when administered in the silent stages of brain tumors; and (e) develop treatment strategies that might improve therapeutic effectiveness and brain function. We adopted a new focal mass compression model providing rapid displacement of tissue in the underlying sensorimotor cortex, as well as the traditional rat and mouse glioma xenograft models that exhibit prominent tumor growth and invasion, given the varied aims and contexts of our different studies. Various conventional and novel brain tumor treatments were employed in this dissertation, including local and systemic chemotherapy, antiangiogenic agents, photodynamic therapy, and a glutamate antagonist. A neurorestorative therapy with atorvastatin was evaluated in its effects on functional recovery after photodynamic therapy. Functional outcomes were measured with an array of behavioral tests, which are sensitive to mild focal insults to the sensorimotor cortex and can detect recovery of function. Histopathological assessments consisted of Nissl staining, hematoxylin-andeosin (H&E) staining, and immunohistochemistry, depending on varied purposes, used in conjunction with a computer imaging analysis system. In clinical trials, functional outcome is as critical to gauging the success of a treatment as is patient survival time. Both preclinical screening of anti-cancer interventions for the ability to shrink tumors effectively with minimal disturbance of neuroplasticity and developing combination therapy with neurorestorative regimens following neurotoxic cancer treatments should allow for optimal promotion of plastic mechanisms in the remaining normal brain tissue.
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Pathobiological study of gestational trophoblastic diseaseCheung, Nga-yin, Annie., 張雅賢. January 1999 (has links)
published_or_final_version / Medicine / Master / Doctor of Medicine
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Immunological studies in gestational trophoblastic disease何柏松, Ho, Pak-chung. January 1989 (has links)
published_or_final_version / Medicine / Master / Doctor of Medicine
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Morphometric studies of odontogenic cysts and tumours張友明, Cheung, Yau-ming. January 1995 (has links)
published_or_final_version / Anatomy / Master / Master of Philosophy
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Antitumor effects and mechanism of actions of Chinese herbalmedicines: a purified coriolus versicolorpeptide and tetrandrine董穎, Dong, Ying. January 1996 (has links)
published_or_final_version / Physiology / Master / Master of Philosophy
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Regulation of mammary tumor cell cycle kinetics and gene expression bydietary fatty acids吳欲勳, Ng, Yuk-fun. January 1998 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
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Differential gene expression in gestational trophoblastic disease方佩儀, Fong, Pui-yee. January 2001 (has links)
published_or_final_version / Pathology / Master / Master of Philosophy
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88 |
Tumour associated macrophages and cytokine expression in humancancers張建南, Cheung, Kin-nam. January 1997 (has links)
published_or_final_version / Pathology / Master / Master of Philosophy
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THE NUCLEIC ACIDS OF AGROBACTERIUM TUMEFACIENS (SMITH AND TOWN.) CONN.Larsen, Philip Otto, 1940- January 1969 (has links)
No description available.
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Using a novel 3-dimensional in vitro spheroid model to investigate new roles for stromal metalloproteinases in tumour angiogenesisCorrêa de Sampaio, Pedro Vaz de Almada January 2012 (has links)
No description available.
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