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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 3 of 3 (0.066 seconds)Spelling suggestions: "subject:"aau isoforms"" "subject:"uau isoforms""
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Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β / 脳幹におけるアルツハイマー病のタウ病変は、3リピート型タウの増加を特徴とし、アミロイドβ蓄積から独立して存在するUematsu, Miho 26 March 2018 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第21010号 / 医博第4356号 / 新制||医||1028(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 井上 治久, 教授 村井 俊哉, 教授 林 康紀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Insights into the mechanism of Tau polymerization and the effects of small moleculesCongdon, Erin Elizabeth 06 August 2007 (has links)
No description available.
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EVALUATION OF AMINOINDOLE CARBOXAMIDES AND TRIAZINES AS POTENTIAL ANTI-AGGREGATION AGENTS OF PROTEIN MISFOLDING DISEASESEduardo Ramirez (18436542) 06 May 2024 (has links)
<p dir="ltr">My research projects focuses on the dual targeting of small molecules to abrogate aberrant α-syn, tau (2N4R), and p-tau (1N4R) aggregation and to reduce the spread of AD and related dementias. Not very many drug discovery programs focus on the specific isoforms of the tau protein. We established two series of compounds: aminoindole compounds connected by a carboxamide and triazine compounds connected by a triazine linker. Using biophysical methods we evaluated the effectiveness of both series of compounds in decreasing the amount of misfolded α-syn and tau protein in order to explore their anti-aggregation potential.</p><p><br></p>
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