With rapid development of technology in industries and aggressive globalization competitiveness, business operation success from the past does not guarantee present and future success, and the competitive advantages of enterprises may vanish after time or environment differences. Promoting new products and process innovation have becoming the main strategies for enterprises, and they also become the key points of the existence of enterprises. Therefore, enterprises should intake technological innovation when formulating strategies, and concentrate on their core resources and capabilities. Through the integrations, the enterprises will be able to react and get the sustainable competitive advantages when changes from outside and inside the organizations occurred. This research is using the Resource-Based View as foundation, and the high technology manufacturers and enterprises in Taiwan as our research objects. Exploring the characteristics of enterprise inner resources, capabilities and the impacts on creating sustainable competitive advantages through the interactions and effects when enterprises engage planning their technological innovation strategies. The obtained data is adapted by Pearson correlation analysis and regression analysis. The research result is hopefully to be able to provide with the high technology manufacturers and enterprises in promoting the competitive advantages in business operation and decision application. The result of this research is that, the technological innovation strategy is indeed affected by core resources and capabilities. The different core resource contents and characteristics have remarkable effects on enterprises technological innovation strategies. This research result is corresponding with resource-strategy paradigm by the Resource-Based School. Technological innovation strategy has outstanding impact on the sustainable competitive advantages. Different types of technological innovation strategies have effects on innovation performances, which shows the importance of applying technological innovation strategy to enhance the competitive advantages. However, the core resource contents and characteristics do not show the direct impact on the sustainable competitive advantages. The core resources and capabilities of enterprises will have contribution to the sustainable competitive advantages by strategy formulation and implementation.