Embora as atividades do pré-desenvolvimento sejam essenciais para o sucesso no desenvolvimento dos produtos, elas têm sido pouco efetivas no alcance dos seus objetivos. Uma das oportunidades para melhorá-las é a integração dos métodos usados no pré-desenvolvimento, os quais têm sido aplicados de forma isolada. Uma revisão bibliográfica mostrou que o technology roadmapping (TRM) e a gestão de portfólio se destacam entre os métodos usados no pré-desenvolvimento. Esse contexto motivou a investigação da pergunta de pesquisa: A aplicação integrada do technology roadmapping e da gestão de portfólio contribui com a realização das atividades do pré-desenvolvimento do PDP?. Assim este trabalho avalia o potencial dessa integração a partir de um estudo de caso em uma pequena empresa de base tecnológica. O estudo de caso utilizou um método desenvolvido pela pesquisa para aplicação integrada do technology roadmapping e da gestão de portfólio, o método ITG. Os resultados obtidos mostraram que a integração beneficiou o pré-desenvolvimento neste caso específico. Entre as contribuições notadas estão: aumento da eficácia do pré-desenvolvimento e o alinhamento das propostas de novos projetos de produtos com as estratégias do negócio, necessidades do mercado e capacidades tecnológicas. Portanto, a integração dos métodos parece constituir um tema com potencial para ajudar as empresas na realização das atividades do pré-desenvolvimento. / Although the front-end activities are critical to the success of NPD, they are in fact almost ineffective in practice. One opportunity to improve them is the integration of methods used in front-end, which have been applied stand-alone. A bibliographical review showed that technology roadmapping (TRM) and portfolio management are stand out methods for the front-end of NPD. This finding motivated the research question of our work: Can the integration of TRM and portfolio management contribute to improve the front-end of NPD? Hence, this work evaluates the potential of this integration based on a case study at a small technology-based company. The study applied a method built in research for integrated application of technology roadmapping and portfolio management, the ITG method. In this specific case, the front-end of NPD benefited from the integration. Among the contributions are: the rising of front-end effectiveness and the alignment of new product project proposals with business strategies, market wants and technological capabilities. Therefore, the methods integration appears to constitute a productive field to help companies in the activities of the NPD front-end.

Embora as atividades do pré-desenvolvimento sejam essenciais para o sucesso no desenvolvimento dos produtos, elas têm sido pouco efetivas no alcance dos seus objetivos. Uma das oportunidades para melhorá-las é a integração dos métodos usados no pré-desenvolvimento, os quais têm sido aplicados de forma isolada. Uma revisão bibliográfica mostrou que o technology roadmapping (TRM) e a gestão de portfólio se destacam entre os métodos usados no pré-desenvolvimento. Esse contexto motivou a investigação da pergunta de pesquisa: A aplicação integrada do technology roadmapping e da gestão de portfólio contribui com a realização das atividades do pré-desenvolvimento do PDP?. Assim este trabalho avalia o potencial dessa integração a partir de um estudo de caso em uma pequena empresa de base tecnológica. O estudo de caso utilizou um método desenvolvido pela pesquisa para aplicação integrada do technology roadmapping e da gestão de portfólio, o método ITG. Os resultados obtidos mostraram que a integração beneficiou o pré-desenvolvimento neste caso específico. Entre as contribuições notadas estão: aumento da eficácia do pré-desenvolvimento e o alinhamento das propostas de novos projetos de produtos com as estratégias do negócio, necessidades do mercado e capacidades tecnológicas. Portanto, a integração dos métodos parece constituir um tema com potencial para ajudar as empresas na realização das atividades do pré-desenvolvimento. / Although the front-end activities are critical to the success of NPD, they are in fact almost ineffective in practice. One opportunity to improve them is the integration of methods used in front-end, which have been applied stand-alone. A bibliographical review showed that technology roadmapping (TRM) and portfolio management are stand out methods for the front-end of NPD. This finding motivated the research question of our work: Can the integration of TRM and portfolio management contribute to improve the front-end of NPD? Hence, this work evaluates the potential of this integration based on a case study at a small technology-based company. The study applied a method built in research for integrated application of technology roadmapping and portfolio management, the ITG method. In this specific case, the front-end of NPD benefited from the integration. Among the contributions are: the rising of front-end effectiveness and the alignment of new product project proposals with business strategies, market wants and technological capabilities. Therefore, the methods integration appears to constitute a productive field to help companies in the activities of the NPD front-end.

The primary aim of the thesis is to contribute to demonstrating how established and emerging science in the regenerative medicine (RM) domain can be translated into profitable commercial practice, and generate clinically- and cost-effective therapies. It achieves this by exploring and assessing underlying economics, including investment readiness and economic assessment, exploring regulatory and reimbursement frameworks, developing stem cell culture systems and assessing fit with clinical practice. The thesis is the first public domain wide-ranging analysis of business trends in the production, manufacturing and supply segments of the RM industry. It analyses the clinical potential of the domain as well as the translational and commercial challenges facing the industry. The industry is at a turning point as big pharmaceutical companies engage with RM in order to explore technologies as potential therapeutics and discovery tools. This unlocks the industry by confirming an exit path for RM based small- and medium-sized enterprises. Translation has come to be recognised as a core issue in the overall space and translation of regenerative therapies into the clinic is presently challenging, high-risk and expensive. This research addresses the question what are the mechanisms required to enable translation of emerging scientific knowledge into commercially viable clinical RM products? These mechanisms are particularly important as their creation involves and requires major investment decisions, which can determine the success or failure of RM developments and indeed of the companies concerned. The lack of well-established business models and the complexity of the domain suggested a conceptual approach drawing upon relevant literature from product and process development, applied business and revenue models, technological evolution and capital market ingenuity. The research was carried out in two phases. The first phase was concerned with identification of key challenges and mapping the overall industry emergence including emergence of related regulations to provide a context and framework for understanding the domain. Based on the emergence mapping a timeline of key parallel factors was identified, and their inherent connections explored to identify transforming events affecting and influencing multiple factors on the journey to clinical success within a business environment. This creates the reference model. The second phase was concerned with manufacturing a stem cell based therapeutic and applying health economic principles to determine available headroom for investment, cost of goods and return on investment, taking hearing disorders as a case exemplar, and exploring the behaviour of the net present value curve to identify key parameters affecting the economic positioning of this novel regime. A key output of the research is the investment readiness reference model. It integrates key RM business issues against reducing uncertainty and increasing value. The model argues that the complex nature of RM products means that the issues affecting industry emergence and development go well beyond the primarily scientific and technological concerns on which much current research focuses. The performance of RM firms ultimately hinges upon the successful clinical application of their developed products, the key step for creating and realising value, and their ability to deal with the fundamental business issues specific to the area. The framework deals with these business issues, which are investment & technology readiness, business models, organisational challenges, public policy and industry emergence. This thesis explores ideas that may bridge the chasm between the promise and reality of RM i.e. mechanisms to enable late stage translation of RM products. It links technological capability and business models for firms in the domain. Furthermore, it offers a unique perspective on the nature and characteristics of investment readiness and financial assessment, specifically identifying key parameters affecting economic positioning. The key contributions are therefore: New insights into the key challenges involved in realising the commercial potential of cell based therapeutics. Technology road mapping to link fundamental enabling technological capability for developing RM products with robust business plans integrating strategy, technology development and the regulatory and reimbursement framework. A generic investment readiness reference model generated from the enabling technology, value and supply chain structures to identify key indicators and characteristics of industry readiness. A novel experimental programme demonstrating expansion, maintenance and differentiation of human embryonic stem cells by manual and automated methods. New insights into economic positioning by mapping net present value, and economic analysis by estimating available headroom, cost of goods and return on investment for a putative hearing therapeutic.

Made available in DSpace on 2016-06-02T19:51:39Z (GMT). No. of bitstreams: 1 2495.pdf: 689346 bytes, checksum: 9c79c3f45b345f035630b8770d19f0b3 (MD5) Previous issue date: 2009-05-27 / Financiadora de Estudos e Projetos / The technology forecast and management methods have been considered by academics and managers important tools to support technology development. Generally the organizations, which are worried about this issues, needs data and information to look ahead and clarify technologies course before it happens. Considering that development s time has become shorter, these kind of methodologies may turn more and more important. Despite of these matters, it s rare to find papers and related cases to this subject in Brazil. That s why this study has the objective of collect and discuss methodologies, and right after that, compare the Technology Roadmap (TRM) to the CNPDIA s method of technology forecast and management. This TRM method is frequently presented in the related magazines. The work realized has compared the dimension of the TRM, considering some extras observations. These extras looks offered a more complete view and understanding of the environment in which the technology activities took place. The expected intention was to collaborate by analyzing some of the CNPDIA s characterizes. One extra hope is to inspire some discussion in the unit observed, based on this work. / Os métodos de prospecção e gestão de tecnologia são importantes instrumentos para a inovação em organizações que visam o desenvolvimento de pesquisas e tecnologia. Em geral, estas organizações precisam de dados, informações e orientações que embasem as decisões acerca das atividades que serão conduzidas. Considerando que as atividades de inovação tecnológica aceleraram-se nestas últimas décadas, reduzindo o tempo de desenvolvimento, a importância deste tipo de metodologia tende a aumentar. Entretanto, no Brasil ainda é escassa a literatura sobre o tema, com poucos relatos de utilização de algumas destas metodologias. Por isso, esta dissertação possui o objetivo de aprofundar este tema. Visa-se coletar e selecionar, das diferentes fontes identificadas, conteúdos relevantes sobre prospecção e gestão de tecnologia para compor uma densa revisão desta literatura e, em seguida, realizar a comparação entre o modelo de prospecção e gestão de tecnologia presente no Centro Nacional de Pesquisas e Desenvolvimento de Instrumentação Agropecuária CNPDIA e o método do Technology Roadmapping, método freqüente em revistas de referência no tema. A comparação foi baseada nas dimensões presentes no Technology Roadmaping, entretanto os limites dimensionais da metodologia foram extrapolados para aprofundar o conhecimento acerca do objeto de estudo. A partir desta compreensão, objetivou-se contribuir ao analisar algumas características desta importante unidade da Embrapa, o CNPDIA. Espera-se, também, que algumas das recomendações realizadas nesta dissertação possam ser alvo de debates na unidade pesquisada.