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A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcoholBrocklesby, K.L., Waby, Jennifer S., Cawthorne, C., Smith, G. 17 September 2019 (has links)
Yes / Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%).
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