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Host response in diabetes-associated periodontitis effects of tetracycline analogues /Ryan, Maria Emanuel. January 1998 (has links)
Thesis (Ph. D.)--State University of New York at Stony Brook, 1998. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Host response in diabetes-associated periodontitis effects of tetracycline analogues /Ryan, Maria Emanuel. January 1998 (has links)
Thesis (Ph. D.)--State University of New York at Stony Brook, 1998. / Includes bibliographical references.
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Identification and quantitative determination of tetracyclines in pharmaceutical preparations by derivative spectrophotometry.January 1990 (has links)
Fung Wai-kwong. / Thesis (M.Phil)--Chinese University of Hong Kong, 1990. / Bibliography: leaves 86-88. / ACKNOWLEDGEMENT / ABSTRACT --- p.1 / Chapter PART I. --- INTRODUCTION --- p.3 / Chapter 1.1 --- General introduction --- p.3 / Chapter 1.2 --- Brief review of the derivative --- p.5 / spectrophotometric method / Chapter PART II. --- IDENTIFICATION OF TETRACYCLINES --- p.13 / Chapter 2.1 --- Introduction --- p.13 / Chapter 2.2 --- Experimental --- p.14 / Chapter 2.3 --- Results and discussion --- p.16 / Chapter 2.4 --- Conclusion --- p.20 / Chapter PART III. --- QUANTITATIVE DETERMINATION OF TETRACYCLINES AND RELATED DRUGS --- p.28 / Chapter 3.1 --- Introduction --- p.28 / Chapter 3.2 --- Experimental --- p.30 / Chapter 3.3 --- Results and discussion --- p.38 / Chapter 3.4 --- Conclusion --- p.82 / References --- p.86
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Multiplicative Expansion of the Pool of Fully Synthetic Tetracycline AntibioticsWright, Peter Maughan 05 March 2013 (has links)
This thesis describes the development of chemical pathways for the preparation of more than 80 novel fully synthetic tetracyclines with structural variability at positions C5 and C5a. Progress toward the synthesis of 5-hetero-tetracyclines, another new class of tetracycline antibiotics, is also described. The results detailed herein – including successful C-ring-forming Michael–Claisen cyclizations of numerous modified AB precursors with just a few of the extraordinarily diverse D-ring precursors known to be effective nucleophiles in this key coupling reaction – represent the first steps toward a multiplicative expansion of the pool of fully synthetic tetracyclines. Novel and versatile \(\beta\)-functionalization reaction sequences employing tris(methylthio)methyllithium and 2-lithio-1,3-dithiane have been developed to transform the AB enone 10 (the key precursor to fully synthetic tetracyclines) into a diverse range of \(\beta\)-substituted AB enone products, including a highly efficient, single-operation method for the synthesis of a \(\beta\)-methyl ester-substituted AB enone (20). It is demonstrated that the six-membered C ring of tetracyclines comprising a C5a quaternary carbon center (e.g. 29) can be assembled by stereocontrolled coupling reactions of \(\beta\)-substituted AB enones and o-toluate ester anion D-ring precursors. A C5a–C11a-bridged cyclopropane tetracycline precursor (37) was found to undergo efficient and regioselective ring-opening reactions with a range of nucleophiles in the presence of magnesium bromide, thus providing another avenue for the preparation of fully synthetic tetracyclines containing an all-carbon quaternary center at position C5a. The AB enone 10 has also been transformed into structurally diverse \(\gamma\)-substituted AB precursors, which in turn have been converted into fully synthetic tetracyclines with unprecedented modifications at position C5, including 5-fluorotetracyclines such as 94. Numerous fully synthetic tetracyclines and tetracycline precursors have been shown to serve as diversifiable branch-points, allowing maximally expedient synthesis of C5- and C5a-substituted tetracyclines by late-stage diversification. The substrate scope of the Michael–Claisen cyclization reaction has been expanded to include new heterocyclic enone electrophiles such as dihydro-4-pyridones, affording cycloadducts such as 142. In this way, the viability of an iterative Michael–Claisen strategy for constructing 5-hetero-tetracyclines has been established. Numerous examples in this thesis serve to further demonstrate the broad applicability of the Michael–Claisen cyclization reaction as a powerful method for the assembly of stereochemically complex six-membered rings. / Chemistry and Chemical Biology
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Primary effects of the tetracyclines on Pseudomonas aeruginosaSergeant, Claire January 1992 (has links)
Pseudomonas aeruginosa grew in the presence of 10 $ mu$g/ml tetracycline (TC) or chlorotetracycline (CTC) in a minimal medium containing Mg$ sp{++}$. Growth is inhibited, with a six-fold increase in length of the lag phase. Cells revert to sensitivity when returned to antibiotic-free medium. Substitution of Mg$ sp{++}$ in the growth medium of CTC-resistant strains with Ca$ sp{++}$ and Sr$ sp{++}$ resulted in dramatic changes in growth and cell mass of cultures. Exposure of CTC-grown cells to EDTA did not result in cell lysis. SDS-PAGE of outer membrane proteins of resistant cells revealed loss of a protein band of molecular weight 73,500 D and the appearance of a 54,000 D protein band. Growth of cells resistant to CTC was hampered by subsequent exposure to penicillin G. Chelation of divalent cations from the outer membrane of sensitive cells leading to cell disruption is postulated as the primary mode of action of this antibiotic against P. aeruginosa.
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Light directed gene patterning using photocaged doxycycline /Sauers, Daniel J. January 2010 (has links)
Thesis (Ph.D.)--University of Delaware, 2009. / Principal faculty advisor: John T. Koh, Dept. of Chemistry & Biochemistry. Includes bibliographical references.
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Primary effects of the tetracyclines on Pseudomonas aeruginosaSergeant, Claire January 1992 (has links)
No description available.
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Effect of achromycin ointment on healing following periodontal surgery a thesis submitted in partial fulfillment ... in periodontics ... /Breloff, Joseph P. January 1981 (has links)
Thesis (M.S.)--University of Michigan, 1981.
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The effects of root conditioning agents on periodontal wound healing a microvascular evaluation : a thesis submitted in partial fulfillment ... in periodontics ... /Doctor, Michael R. January 1989 (has links)
Thesis (M.S.)--University of Michigan, 1989.
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The effects of root conditioning agents on periodontal wound healing a microvascular evaluation : a thesis submitted in partial fulfillment ... in periodontics ... /Doctor, Michael R. January 1989 (has links)
Thesis (M.S.)--University of Michigan, 1989.
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