Millions of people use mobile phone banking daily, and business leaders should understand the factors influencing mobile phone banking adoption among users. Based on the theory of technology acceptance model and the innovation diffusion theory, the purpose of this correlational study was to examine the relationship between usefulness, ease of use, risk, cost, and mobile phone banking adoption in Burkina Faso. One hundred and six mobile phone banking users living in the city of Ouagadougou completed the online survey created to measure consumers understanding of mobile phone banking. Results of the multiple linear regression analysis indicated a statistically significant relationship between the predictor variables and mobile phone banking adoption, F(5,101) = 36.07, p < .001. Three of the predictors contributed significantly to the model, with usefulness recording the highest beta value (Ã? = .692), cost the next highest beta value (Ã? = .225), and ease of use the next highest beta value (Ã? = .173). The 4th predictor, risk, did not contribute significantly to the model, recording a negative beta value (Ã? = -.058). Results may enhance local business leaders' understanding of mobile phone banking adoption, which could result in more effective business strategies to increase the affordability, availability, and quality of mobile banking services for Burkina Faso residents. Development of the mobile phone banking industry could enable business leaders to foster access to affordable financial services for individuals and contribute to the development of Burkina Faso's local economy and trade.