After a short introduction concerning the problem of "Artificial Intelligence" (AI) the work continues with a summary of the state of the art.Thereafter, it goes on to profile four different basic scientific views of human beings and AI: symbolism, connectionism, biologism and physicalism. The emphasis is on the elucidation of anthropologically relevant statements to intelligence, spirit, thinking, perception, will, consciousness, self-consciousness, feelings and life.It is demonstrated that the basic views referred to represent greatly abbreviated and distorted pictures of human beings. Theories that do not go beyond the quantifiable level cannot adequately encompass the nature of relevant concepts and capabilities. That is above all because of the fact that generally a philosophical materialism is advocated, which considers the existence of intellectual substances impossible. For this reason a philosophical critique is necessary. The position of moderate and critical realism is advocated, whose anthropological statements are secured by epistemological and metaphysical investigations.The work comes to the conclusion that human beings cannot be understood symbolistically, connectionistically, biologistically or physicalistically. Man is a physical-intellectual entity, endowed with reason, a living social being. He is formed and led by his intellectual and therefore immortal soul, which gives him uniqueness, irreplaceability and the value of personhood. He is capable of thinking and thus of objective, abstract perception, and therefore is intelligent. Humans have an unfettered will, which, led by mental perception, is to be directed toward the good. They are moreover, through reflection, self-conscious. Humans live an intellectually determined life, which essentially differs, despite biological similarity, from that of animals and cannot possibly, due to its substantial superiority, have developed from animal life.All substantial anthropological abilities (such as intelligence, will, consciousness etc.) presuppose spirit. Because it is not within the power of human beings to create a simple substance such as spirit, a thinking, perceptive, intelligent, willing, self-conscious, sentient living being can at best be only technically imitated, modelled or simulated but never be reproduced, copied or created. The relationship of humans to AI is thus determined by an insuperable difference between their natures.