Thesis (doctoral)--Københavns Universitet. / Bibliography: p. 90-110.

Thesis (M.A. in Physiology)--University of California, Berkeley, Sept. 1959. / Includes bibliographical references (leaves 32-36).

Thesis (doctoral)--Københavns Universitet. / Bibliography: p. 90-110.

Chum salmon eggs were immersed in thyroxine, in thiourea, in halide salts, and in adrenalin on the day of fertilization and were maintained in these solutions until several months after hatching. All treatments affected growth either favourably or adversely, but only thyroxine and chloride changed body proportions. The changes due to chloride were significantly smaller than those following thyroxine treatment, and it is postulated that they are not “thyroxine-like” in nature. Thiourea inhibited colloid function with the usual hypertrophy and hyperplasia of the gland. Chloride and bromide depressed the heart rate significantly, whilst the other treatments had no effect. Iodide and bromide dispersed melanin pigment but thyroxine concentrated it slightly and adrenalin maximally so that adrenalin treated live fish were very pale. Thyroxine increased markedly the deposition of guanine and must, therefore, accelerate the hydrolysis of nuclear purines. It is concluded that specific effects produced by thyroxine in developing chum salmon are not duplicated by the halides and adrenalin. / Science, Faculty of / Zoology, Department of / Graduate

The graduate studies of the writer began at Brigham Young University in the Autunm of 1951, at which time he filed his intention of majoring in Zoology and minoring in Chemistry. During the first three quarters he received instruction under his committee chairman in a sequence of courses entitled: "Body Fluids", "Neurology", and "Endocrinology". During the first of these three courses the role of the kidneys in the maintenance of a relatively constant internal environment was discussed. During the course in Endocrinology the following statement was found in the text which suggested that the thyroid hormone might have an influence on the part of the kidney function involved in the maintenance of a rather constant blood clucose concentration: The metabolism of carbohydrates .... is influenced by the functional state of the thyroid gland .... the rate of absorption of sugar from the intestinal tract is low in thyroidectomized animals and high in hyperthyroid individuals. However, no direct reference we.s found in this text about the thyroid hormone and kidney function.

Thesis (doctoral)--Katholieke Universiteit te Nijmegen.

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Since the isolation of triiodothyronine (T3) by Pitt-Rivers and Gross (1953) several questions as to its role as a thyroid hormone arose. Does T3 have the same or different actions than that of thyroxine (T4 )? Is T3 an emergency hormone, since its synthesis relative to T4 is greatly increased during periods of low iodine intake and its response time is I/5th that of T4 (Ackerman and Arons, 1958)? Are there any interactions modifying their respective actions?