One of the objectives of this research was to evaluate the need for an additional imidacloprid seed treatment on ThryvOn® (Bayer Crop Science®, St. Louis, MO) cotton to effectively manage tobacco thrips, Frankliniella fusca (Hinds). While evaluating thrips densities and damage ratings, ThryvOn cotton continued to display reduced damage and thrips populations than non-ThryvOn. Thrips populations and damage ratings were consistently reduced when incorporating a higher rate of imidacloprid, but they were not reduced enough to justify the higher rates of imidacloprid. Another objective of this research was to evaluate the impact of aldicarb (AgLogic Chemical®, LLC; Chapel Hill, NC) and ThryvOn on reniform nematode, Rotylenchulus reniformis (Linford & Oliveira). The impact of aldicarb and ThryvOn technology had no impact on reniform nematode densities in Mississippi cotton throughout this study. The reduced thrips populations and damage ratings provided by ThryvOn cotton has the potential to improve integrated pest management in the southern U.S.