Administration of nasal cannula therapy tasks providers with periodically monitoring their patients and adjusting settings according to patient needs. Conventionally, providers monitor a patient's oxygen demand using pulse oximetry and a qualitative assessment of the patient's work of breathing. The motivation for this research is to augment the traditional qualitative assessment of work of breathing with a quantitative measurement of a patient's tidal volume, the volume of air inhaled with each breath. This thesis presents a novel approach to measure tidal volume using a nasal cannula with built-in pressure sensors. Pressure waveforms obtained from continuous measurement of the pressure at the tip of the cannula are used to estimate nasal flowrates, and these nasal flowrates are time-integrated to estimate tidal volumes. Computational fluid dynamics (CFD) models were used to simulate fluid flow in a simplified nasal passage undergoing nasal cannula therapy. These simulations used a range of flow conditions characteristic of both low-flow and high-flow nasal cannula treatments. The simulations produced a transformation from cannula tip pressure to instantaneous nasal flowrate, and this transformation was evaluated using a matching empirical experiment. This empirical experiment used a matching physical geometry with a similar range of flow conditions, and the transformation obtained from CFD was able to estimate the actual tidal volumes with 85% accuracy. This study showed that continuous pressure measurement at the tip of a nasal cannula produces enough information to estimate nasal flowrates and tidal volumes. No similar studies were found during the literature review, so an accuracy of 85% is promising for this stage. If this technique could be made more accurate and deployed in an unobtrusive way, the resulting nasal cannula device could be used to continuously, comfortably monitor patients' tidal volumes. / Master of Science / Oxygen therapy is the most common prescription in hospitals across the United States, and the most common form of oxygen therapy is nasal cannula therapy. Administration of nasal cannula therapy requires providers to periodically assess their patients' oxygen saturations and work of breathing. Oxygen saturation can be quantitatively monitored using pulse oximetry but work of breathing must be qualitatively monitored using visual exams or walking tests. The motivation of this research is to augment this qualitative assessment with a quantitative metric. In our research, we chose the volume of inhaled air (the "tidal volume") as a proxy metric for a patient's work of breathing. This thesis presents our attempt to use a nasal cannula augmented with pressure sensors to estimate the tidal volume of a mannequin undergoing nasal cannula therapy. Our concept is that more intense inhalations/exhalations produce larger pressure swings at the tip of the nasal cannula. For this proof-of-concept study, a simplified nasal passage geometry was used. Pressure waveforms obtained from continuous measurement of the pressure at the tip of the cannula are used to estimate nasal flowrates, and these nasal flowrates are time-integrated to estimate tidal volumes. Computational fluid dynamics (CFD) simulations were used to predict how the cannula tip pressure changes as a function of nasal flowrates and cannula flowrates, then this relationship was tested using a matching empirical experiment. This matching empirical experiment showed that our technique of estimating tidal volumes was 85% accurate. This study showed that continuous pressure measurement at the tip of a nasal cannula produces enough information to estimate nasal flowrates and tidal volumes. No similar studies were found during the literature review, so an accuracy of 85% is promising for this stage. If this technique could be made more accurate and deployed in an unobtrusive way, the resulting nasal cannula device could be used to continuously, comfortably monitor patients' tidal volumes.